Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …

Objective Delirium is a complex neurocognitive syndrome suspected to be bidirectionally
linked to dementia. Circadian rhythm disturbances likely contribute to dementia …

BACKGROUND The kynurenine pathway (KP) has been identified as a potential mediator
linking acute illness to cognitive dysfunction by generating neuroactive metabolites in …

Frailty is a geriatric condition characterized by the reduction of the individual's homeostatic
reserves. It determines an increased vulnerability to endogenous and exogenous stressors …

Background Previous population-based, longitudinal studies have shown that delirium is
associated with an increased risk of dementia and cognitive decline. However, the …

Methods We adopted an identical search strategy to a previous systematic review, only
including studies using a recognised diagnostic framework for ascertaining delirium at follow …

Background Hearing loss and dementia are highly prevalent in older age and often co-
occur. Most neurocognitive screening tests are auditory-based, and performance can be …

Delirium presents formidable challenges: it affects one in four of older hospitalised adults,
greatly elevates the risk of multiple short-and long-term complications including dementia …

Background The increased risk of dementia after delirium and infection might be influenced
by cerebral white matter disease (WMD). In patients with transient ischaemic attack (TIA) and …

Although delirium is a significant clinical and public health problem, little is understood
about how specific vulnerabilities underlie the severity of its presentation. Our objective was …