Drug addiction: hyperkatifeia/negative reinforcement as a framework for medications development
Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
The role of neuroimmune signaling in alcoholism
Alcohol consumption and stress increase brain levels of known innate immune signaling
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …
Gut microbiota-induced changes in β-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder
S Leclercq, T Le Roy, S Furgiuele, V Coste, LB Bindels… - Cell Reports, 2020 - cell.com
Patients with alcohol use disorder (AUD) present with important emotional, cognitive, and
social impairments. The gut microbiota has been recently shown to regulate brain functions …
social impairments. The gut microbiota has been recently shown to regulate brain functions …
[HTML][HTML] Neuroimmune signaling in alcohol use disorder
Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …
Glial and neuroimmune mechanisms as critical modulators of drug use and abuse
Drugs of abuse cause persistent alterations in synaptic plasticity that may underlie addiction
behaviors. Evidence suggests glial cells have an essential and underappreciated role in the …
behaviors. Evidence suggests glial cells have an essential and underappreciated role in the …
Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals
Binge drinking, the most common form of alcohol consumption, is associated with increased
mortality and morbidity; yet, its biological consequences are poorly defined. Previous studies …
mortality and morbidity; yet, its biological consequences are poorly defined. Previous studies …
Mechanisms of neuroimmune gene induction in alcoholism
FT Crews, RP Vetreno - Psychopharmacology, 2016 - Springer
Rationale Alcoholism is a primary, chronic relapsing disease of brain reward, motivation,
memory, and related circuitry. It is characterized by an individual's continued drinking …
memory, and related circuitry. It is characterized by an individual's continued drinking …
High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence
FT Crews, L Qin, D Sheedy, RP Vetreno, J Zou - Biological psychiatry, 2013 - Elsevier
BACKGROUND: Innate immune gene expression is regulated in part through high mobility
group box 1 (HMGB1), an endogenous proinflammatory cytokine, that activates multiple …
group box 1 (HMGB1), an endogenous proinflammatory cytokine, that activates multiple …
Impact of the innate immune response in the actions of ethanol on the central nervous system
J Montesinos, S Alfonso‐Loeches… - Alcoholism: Clinical …, 2016 - Wiley Online Library
The innate immune response in the central nervous system (CNS) participates in both
synaptic plasticity and neural damage. Emerging evidence from human and animal studies …
synaptic plasticity and neural damage. Emerging evidence from human and animal studies …
Induction of innate immune genes in brain create the neurobiology of addiction
FT Crews, J Zou, L Qin - Brain, behavior, and immunity, 2011 - Elsevier
Addiction occurs through repeated abuse of drugs that progressively reduce behavioral
control and cognitive flexibility while increasing limbic negative emotion. Recent discoveries …
control and cognitive flexibility while increasing limbic negative emotion. Recent discoveries …