Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

The gene encoding the receptor-tyrosine kinase RET was first discovered more than three
decades ago, and activating RET rearrangements and mutations have since been identified …

Activating receptor tyrosine kinase RET (rarranged during transfection) gene alterations
have been identified as oncogenic in multiple malignancies. RET gene rearrangements …

The rearranged during transfection (RET) proto-oncogene was identified in 1985 and, very
soon thereafter, a rearrangement named RET/PTC was discovered in papillary thyroid …

Thyroid cancer is a common type of endocrine malignancy, and its incidence has been
steadily increasing in many regions of the world. Initiation and progression of thyroid cancer …

The advent of massively parallel sequencing technologies has allowed the characterization
of cancer genomes at an unprecedented resolution. Investigation of the mutational …

Following the identification of the BCR-ABL1 (Breakpoint Cluster Region-ABelson murine
Leukemia) fusion in chronic myelogenous leukemia, gene fusions generating chimeric …

Whole genome sequencing approaches have provided unprecedented insights into the
genetic lesions responsible for the onset, progression and dedifferentiation of various types …

Thyroid carcinoma is the most frequent endocrine cancer accounting for 5–10% of thyroid
nodules. Papillary histotype (PTC) is the most prevalent form accounting for 80% of all …

At physiological concentrations, reactive oxygen species (ROS), including superoxide
anions and H 2 O 2, are considered as second messengers that play key roles in cellular …