Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Chiral amines are key structural motifs present in a wide variety of natural products, drugs,
and other biologically active compounds. During the past decade, significant advances have …

Mechanochemical reactions by milling, grinding or other types of mechanical action have
emerged as a salient green approach because of its wide applications towards academic …

Asymmetric reductive amination (ARA) of a prochiral carbonyl compound with an amine
using a H2/hydrogen surrogate is a concise and operationally simple method for the …

Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …

Thermochemical conversion of fossil resources into fuels, chemicals, and materials has
rapidly increased atmospheric CO2 levels, hindering global efforts toward achieving carbon …

The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

The asymmetric addition of an N–H bond to various alkenes via a direct catalytic method is a
powerful way of synthesizing value-added chiral amines. Therefore, the enantio-and …

Hydroamination of alkenes, the addition of the N–H bond of an amine across an alkene, is a
fundamental, yet challenging, organic transformation that creates an alkylamine from two …

Electrosynthetic techniques are gaining prominence across the fields of chemistry,
engineering and energy science. However, most works within the direction of synthetic …