The results of many studies in a variety of species have significantly advanced our
understanding of the role of visual experience and the mechanisms of postnatal eye growth …

The zebrafish (Danio rerio) is now the pre-eminent vertebrate model system for clarification
of the roles of specific genes and signaling pathways in development. The zebrafish …

Holt-Oram syndrome is one of the autosomal dominant human 'heart-hand'disorders, with a
combination of upper limb malformations and cardiac defects. Holt-Oram syndrome is …

In an effort to identify the cellular events that enable neuronal regeneration in the vertebrate
retina, the identity and characteristics of mitotic and apoptotic cells were examined in …

The zebrafish has become an important vertebrate model organism to study the
development of the visual system. Mutagenesis projects have resulted in the identification of …

Model systems provide an invaluable tool for investigating the molecular mechanisms
underlying the NCLs, devastating neurodegenerative disorders that affect the relatively …

The need for mouse models, with their well‐developed genetics and similarity to human
physiology and anatomy, is clear and their central role in furthering our understanding of …

neuroD is a member of the family of proneural genes, which function to regulate the cell
cycle, cell fate determination and cellular differentiation. In the retinas of larval and adult …

The WNK1 (WNK lysine deficient protein kinase 1) protein is a serine/threonine protein
kinase with emerging roles in cancer. WNK1 causes hypertension and hyperkalemia when …

Substance abuse is a significant public health concern both domestically and worldwide.
The persistent use of substances regardless of aversive consequences forces the user to …