Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators
Neurotransmitters and neuromodulators have a wide range of key roles throughout the
nervous system. However, their dynamics in both health and disease have been challenging …
nervous system. However, their dynamics in both health and disease have been challenging …
Fluorescent proteins and genetically encoded biosensors
M Wang, Y Da, Y Tian - Chemical Society Reviews, 2023 - pubs.rsc.org
The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …
light. They are powerful tools for the visualisation of physiological processes in living cells …
A tissue-like neurotransmitter sensor for the brain and gut
Neurotransmitters play essential roles in regulating neural circuit dynamics both in the
central nervous system as well as at the peripheral, including the gastrointestinal tract …
central nervous system as well as at the peripheral, including the gastrointestinal tract …
Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors
INTRODUCTION Neuromodulators, such as dopamine, norepinephrine, or serotonin, exert
powerful control over neural circuit dynamics that give rise to diverse neural function and …
powerful control over neural circuit dynamics that give rise to diverse neural function and …
Structure-and mechanism-guided design of single fluorescent protein-based biosensors
Intensiometric genetically encoded biosensors, based on allosteric modulation of the
fluorescence of a single fluorescent protein, are powerful tools for enabling imaging of …
fluorescence of a single fluorescent protein, are powerful tools for enabling imaging of …
A gut-brain neural circuit for nutrient sensory transduction
INTRODUCTION In 1853, Sydney Whiting wrote in his classic Memoirs of a Stomach,“… and
between myself and that individual Mr. Brain, there was established a double set of electrical …
between myself and that individual Mr. Brain, there was established a double set of electrical …
A genetically encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice
Dopamine (DA) is a central monoamine neurotransmitter involved in many physiological
and pathological processes. A longstanding yet largely unmet goal is to measure DA …
and pathological processes. A longstanding yet largely unmet goal is to measure DA …
Glutamatergic signaling in the central nervous system: ionotropic and metabotropic receptors in concert
A Reiner, J Levitz - Neuron, 2018 - cell.com
Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as
a key neuromodulator to control synapse and circuit function over a wide range of spatial …
a key neuromodulator to control synapse and circuit function over a wide range of spatial …
A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine
Norepinephrine (NE) is a key biogenic monoamine neurotransmitter involved in a wide
range of physiological processes. However, its precise dynamics and regulation remain …
range of physiological processes. However, its precise dynamics and regulation remain …
An expanded palette of dopamine sensors for multiplex imaging in vivo
Genetically encoded dopamine sensors based on green fluorescent protein (GFP) enable
high-resolution imaging of dopamine dynamics in behaving animals. However, these GFP …
high-resolution imaging of dopamine dynamics in behaving animals. However, these GFP …