Maternal mortality rates are at an all-time high across the world and are set to increase in
subsequent years. Cardiovascular disease is the leading cause of death during pregnancy …

A substantial number of patients are at high-risk of intra-or post-operative complications or
both. Most perioperative deaths are represented by patients who present insufficient …

Abstract Mitochondrial disorders affect 1/5,000 and have no cure. Inducing mitochondrial
biogenesis with bezafibrate improves mitochondrial function in animal models, but there are …

Age-related changes in cardiac and vascular function are associated with increased risk of
cardiovascular mortality and morbidity. The aim of the present study was to define the effect …

Background. Non-invasive cardiac output monitoring (NICOM) using bioreactance (BRT) in
pregnancy is gaining interest but lacks validation. We compared simultaneous cardiac …

Purpose Less than 10% of heart failure patients in the UK participate in cardiac rehabilitation
programmes. The present pilot study evaluated feasibility, acceptability and physiological …

Cardiac output is a key parameter in the assessment of cardiac function, and its
measurement is fundamental to the diagnosis, treatment, and prognostic evaluation of all …

Introduction It is known that maximum oxygen uptake depends on age, sex, endurance
capacity, and chronic heart failure. However, due to the required invasive or often applied …

Background—Conventional cardiopulmonary exercise testing can objectively measure
exercise intolerance but cannot provide comprehensive evaluation of physiology. This …

Objective Exercise intolerance is a clinical hallmark of chronic conditions. The present study
determined pathophysiological mechanisms of exercise intolerance in cardiovascular …