Nitric oxide (NO) is an important vasodilator and regulator in the cardiovascular system, and
this link was the subject of a Nobel prize in 1998. However, NO also plays many other …

SUMMARY 1 The present review discusses the potential role of nitric oxide (NO) in the:(i)
regulation of skeletal muscle glucose uptake during exercise; and (ii) activation of …

5-Aminoimidazole-4-carboxamide-ribonucleoside (AICAR) and caffeine, which activate AMP-
activated protein kinase (AMPK) and cause sarcoplasmic reticulum calcium release …

Key points AMP‐activated protein kinase (AMPK) is considered a major regulator of skeletal
muscle metabolism during exercise. However, we previously showed that, although AMPK …

PURPOSE: We have previously shown that local infusion of a nitric oxide synthase (NOS)
inhibitor attenuates increases in leg glucose uptake during exercise in humans. We have …

A high-fat diet (HFD) and overweight status can induce hippocampal dysfunction, leading to
depression and anxiety. Exercise has beneficial effects on emotional behaviors. We …

Aim: Exercise and insulin each increase microvascular blood flow and enhance glucose
disposal in skeletal muscle. We have reported that insulin‐mediated microvascular …

Key points People with insulin resistance or type 2 diabetes can substantially increase their
skeletal muscle glucose uptake during exercise and insulin sensitivity after exercise …

Skeletal muscle AMPK is not activated during 2 h of moderate intensity exercise at ∼65%
V̇₀₂peak in endurance trained me Page 1 Skeletal muscle AMPK is not activated during 2 h …

A adenosina é uma substância ubíqua que está envolvida no controlo de vários processos
fisiológicos, entre os quais a sensibilização da ação da insulina e a homeostasia da …