A small sugar molecule with huge potential in targeted cancer therapy

G Pastuch-Gawołek, J Szreder, M Domińska, M Pielok… - Pharmaceutics, 2023 - mdpi.com
The number of cancer-related diseases is still growing. Despite the availability of a large
number of anticancer drugs, the ideal drug is still being sought that would be effective …

Semisynthetic derivatives of pentacyclic triterpenes bearing heterocyclic moieties with therapeutic potential

G Nistor, C Trandafirescu, A Prodea, A Milan, A Cristea… - Molecules, 2022 - mdpi.com
Medicinal plants have been used by humans since ancient times for the treatment of various
diseases and currently represent the main source of a variety of phytocompounds, such as …

Liposomal form of 2-alkylthioimidazolone-based copper complexes for combined cancer therapy

TM Iakimova, AA Bubley, OP Boychenko, DA Guk… - …, 2023 - Taylor & Francis
Aim: To develop an optimized approach for encapsulating a 2-alkylthioimidazolone-based
copper coordination compound within liposomes, which could offer treatment of cancer and …

In Vitro/In Vivo Electrochemical Detection of Pt(II) Species

AN Vaneev, PV Gorelkin, OO Krasnovskaya… - Analytical …, 2022 - ACS Publications
The biodistribution of chemotherapy compounds within tumor tissue is one of the main
challenges in the development of antineoplastic drugs, and techniques for simple …

Development of asialoglycoprotein-mediated hepatocyte-targeting antitumor prodrugs triggered by glutathione

M Wang, Z Li, F Liu, Q Yi, C Pu, Y Li, T Luo… - Journal of Medicinal …, 2021 - ACS Publications
One antitumor β-elemene derivative W-105 and three novel hepatocyte-targeting prodrugs
(W-1-5, W-2-9, and W-3-8) were designed and synthesized. W-105 (IC50 6.107 μM) could …

Design, synthesis and biological evaluation of the positional isomers of the galactose conjugates able to target hepatocellular carcinoma cells via ASGPR-mediated …

W Ye, Q Tang, T Zhou, C Zhou, C Fan, X Wang… - European Journal of …, 2024 - Elsevier
Galactose as a recognizing motif for asialoglycoprotein receptor (ASGPR) is a widely
accepted vector to deliver cytotoxic agents in the therapy of hepatocellular carcinoma …

Angelica Sinensis Polysaccharide-Based Nanoparticles for Liver-Targeted Delivery of Oridonin

H Sun, J Nai, B Deng, Z Zheng, X Chen, C Zhang… - Molecules, 2024 - mdpi.com
The present work aimed to study the feasibility of Angelica sinensis polysaccharide (ASP) as
an instinctive liver targeting drug delivery carrier for oridonin (ORI) in the treatment of …

Recent progress on triterpenoid derivatives and their anticancer potential

ZX Zhao, QY Zou, YH Ma, SL Morris‐Natschke, XY Li… - Phytochemistry, 2024 - Elsevier
Cancer poses a significant global public health challenge, with commonly used adjuvant or
neoadjuvant chemotherapy often leading to adverse side effects and drug resistance …

Intravital electrochemical nanosensor as a tool for the measurement of reactive oxygen/nitrogen species in liver diseases

T Abakumova, A Vaneev, V Naumenko… - Journal of …, 2022 - Springer
Reactive oxygen/nitrogen species (ROS/RNS) are formed during normal cellular metabolism
and contribute to its regulation, while many pathological processes are associated with …

Multivalent Lactobionic Acid and N‐Acetylgalactosamine‐Conjugated Peptide Nucleic Acids for Efficient In Vivo Targeting of Hepatocytes

V Kumar, A Wahane, A Gupta… - Advanced …, 2023 - Wiley Online Library
Peptide nucleic acids (PNAs) are used/applied in various studies to target genomic DNA
and RNA to modulate gene expression. Non‐specific targeting and rapid elimination always …