Mechanisms of bone development and repair
A Salhotra, HN Shah, B Levi… - Nature reviews Molecular …, 2020 - nature.com
Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …
formation of the body scaffold. The repair potential of bone and its surrounding …
[HTML][HTML] FGF/FGFR signaling in health and disease
Y Xie, N Su, J Yang, Q Tan, S Huang, M Jin… - Signal transduction and …, 2020 - nature.com
Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …
signaling has crucial roles in a multitude of processes during embryonic development and …
The fibroblast growth factor signaling pathway
DM Ornitz, N Itoh - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
Exploring mechanisms of FGF signalling through the lens of structural biology
R Goetz, M Mohammadi - Nature reviews Molecular cell biology, 2013 - nature.com
Fibroblast growth factors (FGFs) mediate a broad range of functions in both the developing
and adult organism. The accumulated wealth of structural information on the FGF signalling …
and adult organism. The accumulated wealth of structural information on the FGF signalling …
Fibroblast growth factors: key players in regeneration and tissue repair
L Maddaluno, C Urwyler, S Werner - Development, 2017 - journals.biologists.com
Tissue injury initiates a complex repair process, which in some organisms can lead to the
complete regeneration of a tissue. In mammals, however, the repair of most organs is …
complete regeneration of a tissue. In mammals, however, the repair of most organs is …
The FGF family: biology, pathophysiology and therapy
A Beenken, M Mohammadi - Nature reviews Drug discovery, 2009 - nature.com
The family of fibroblast growth factors (FGFs) regulates a plethora of developmental
processes, including brain patterning, branching morphogenesis and limb development …
processes, including brain patterning, branching morphogenesis and limb development …
Mechanisms of angiogenesis and arteriogenesis
P Carmeliet - Nature medicine, 2000 - nature.com
Endothelial and smooth muscle cells interact with each other to form new blood vessels. In
this review, the cellular and molecular mechanisms underlying the formation of endothelium …
this review, the cellular and molecular mechanisms underlying the formation of endothelium …
Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
N Itoh, DM Ornitz - The Journal of Biochemistry, 2011 - academic.oup.com
Fibroblast growth factors (FGFs) are a family of structurally related polypeptides that are
essential for embryonic development and that function postnatally as homoeostatic factors …
essential for embryonic development and that function postnatally as homoeostatic factors …
Controlling organoid symmetry breaking uncovers an excitable system underlying human axial elongation
The human embryo breaks symmetry to form the anterior-posterior axis of the body. As the
embryo elongates along this axis, progenitors in the tail bud give rise to tissues that …
embryo elongates along this axis, progenitors in the tail bud give rise to tissues that …
[HTML][HTML] Fibroblast growth factors
DM Ornitz, N Itoh - Genome biology, 2001 - Springer
Fibroblast growth factors (FGFs) make up a large family of polypeptide growth factors that
are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members …
are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members …