Vaccines are one of the most powerful technologies supporting public health. The adaptive
immune response induced by immunization arises following appropriate activation and …

Aliphatic polyesters prepared by ring-opening polymerization of lactones are now used
worldwide as bioresorbabale devices in surgery (orthopaedic devices, sutures, stents, tissue …

abstract Due to the excellent safety profile of poly (D, L-lactide-co-glycolide)(PLGA) particles
in human, and their biodegradability, many studies have focused on the application of PLGA …

Whether vaccines are designed to prepare the immune system for the encounter with a
pathogen or with cancer, certain common challenges need to be faced, such as what …

Currently, aluminum salts and MF59 are the only vaccine adjuvants approved for human
use. With the development of new-generation vaccines (including recombinant subunit and …

Injectable biodegradable polymeric particles (usually microspheres) represent an exciting
approach to control the release of vaccine antigens to reduce the number of doses in the …

Background Pulmonary route is an attractive target for both systemic and local drug delivery,
with the advantages of a large surface area, rich blood supply, and absence of first-pass …

For humans, companion animals, and food producing animals, vaccination has been touted
as the most successful medical intervention for the prevention of disease in the twentieth …

Hydrogels are very attractive delivery systems for hydrophilic macromolecules such as
proteins and DNA because they provide a protective environment and allow control of …

New generation vaccines will increasingly comprise highly purified recombinant proteins.
Unfortunately, these antigens are often poorly immunogenic. Therefore, adjuvants will be …