Regulation of breast cancer metastasis signaling by miRNAs

BJ Petri, CM Klinge - Cancer and metastasis reviews, 2020 - Springer
Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

NDK/NME proteins: a host–pathogen interface perspective towards therapeutics

A Gupta, KM Sinha, MZ Abdin, N Puri, A Selvapandiyan - Current Genetics, 2021 - Springer
No effective vaccine is available for any parasitic disease. The treatment to those is solely
dependent on chemotherapy, which is always threatened due to development of drug …

[HTML][HTML] The eEF1 family of mammalian translation elongation factors

BS Negrutskii, VF Shalak, OV Novosylna, LV Porubleva… - BBA advances, 2023 - Elsevier
The eEF1 family of mammalian translation elongation factors is comprised of the two
variants of eEF1A (eEF1A1 and eEF1A2), and the eEF1B complex. The latter consists of …

A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation

O Ernst, J Sun, B Lin, B Banoth, MG Dorrington… - Science …, 2021 - science.org
Noncanonical inflammasome activation by cytosolic lipopolysaccharide (LPS) is a critical
component of the host response to Gram-negative bacteria. Cytosolic LPS recognition in …

Assessment of the Anticancer Potentials of the Free and Metal-Organic Framework (UiO-66)–Delivered Phycocyanobilin

SA Rashed, SF Hammad, MM Eldakak, IA Khalil… - Journal of …, 2023 - Elsevier
Phycocyanin (C-PC) is a constitutive chromoprotein of Arthrospira platensis, which exhibits
promising efficacy against different types of cancer. In this study, we cleaved C-PC's …

Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients

MK Leonard, GS Puts, N Pamidimukkala, G Adhikary… - Oncogene, 2021 - nature.com
Hepatocyte growth factor-overexpressing mice that harbor a deletion of the Ink4a/p16 locus
(HP mice) form melanomas with low metastatic potential in response to UV irradiation. Here …

The subcellular localization and oligomerization preferences of NME1/NME2 upon radiation-induced DNA damage

M Radić, M Šoštar, I Weber, H Ćetković… - International journal of …, 2020 - mdpi.com
Nucleoside diphosphate kinases (NDPK/NME/Nm23) are enzymes composed of subunits
NME1/NDPK A and NME2/NDPK B, responsible for the maintenance of the cellular (d) NTP …

Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells

B Negrutskii - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
The human translation machinery includes three types of supramolecular complexes
involved in elongation of the polypeptide chain: the ribosome, complex of elongation factors …

[HTML][HTML] Comprehensive analysis of the NME gene family functions in breast cancer

H Wu, X Huang, S Chen, S Li, J Feng… - Translational Cancer …, 2020 - ncbi.nlm.nih.gov
Background An increasing amount of research over recent years on the anti-metastasis
function of the non-metastatic (NME) gene family has been challenged, with some studies …

[HTML][HTML] MicroRNA-139-5p negatively regulates NME1 expression in hepatocellular carcinoma cells

J Yang, DZ Li, Y Pang, T Zhou, J Sun… - … in Clinical and …, 2022 - advances.umw.edu.pl
Background. High expression of NME1 is associated with hepatocellular carcinoma (HCC)
progression and poor prognosis. However, there are few reports on the association between …