Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

PIWI-interacting RNAs (piRNAs) are small non-coding RNAs enriched in animal gonads
where they repress transposons to maintain genome integrity. Because of the highly tissue …

Retrotransposons play an important role in genome evolution but pose acute challenges to
host genome integrity, particularly in early stage germ cells where epigenetic control is …

We conducted PrediXcan analysis of hydrocephalus risk in ten neurological tissues and
whole blood. Decreased expression of MAEL in the brain was significantly associated …

Nucleic acid binding proteins regulate transcription, splicing, RNA stability, RNA localization,
and translation, together tailoring gene expression in response to stimuli. Upon discovery …

Transposable elements (TE) are mobile DNA sequences whose excessive proliferation
endangers the host. Although animals have evolved robust TE-targeting defenses, including …

Sox proteins are known as crucial transcription factors for many developmental processes
and for a wide range of common diseases. They were believed to specifically bind and bend …

Germ granules are protein-RNA condensates that segregate with the embryonic germline. In
Caenorhabditis elegans embryos, germ (P) granule assembly requires MEG-3, an …

There is a growing body of evidence that a substantial number of protein domains identified
as DNA-binding also interact with RNA to regulate biological processes. Several recent …