The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …

Endothelial dysfunction leading to vascular leak is the hallmark of severe dengue. Vascular
leak typically becomes clinically evident 3–6 days after the onset of illness, which is known …

Dengue virus infection presents a wide spectrum of manifestations including asymptomatic
condition, dengue fever (DF), or severe forms, such as dengue hemorrhagic fever (DHF) and …

Highlights•Biomarkers of severe dengue can potentially improve clinical dengue outcomes
and alleviate the healthcare burden in dengue-endemic settings.•Risk factors for severe …

Several viruses are recognized as the direct or indirect causative agents of human tumors
and other severe human diseases. Vascular endothelial growth factor (VEGF) is identified as …

Homeostasis of small blood vessels exerts a powerful influence on the disease course in
critically ill patients. In systemic inflammation, dysregulated microvessels throughout the …

The current pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). While this respiratory virus only causes …

Dengue is the most rapidly emerging climate-sensitive infection, and morbidity/mortality and
disease incidence are rising markedly, leading to healthcare systems being overwhelmed …

Dengue virus (DENV) is a leading cause of illness and death, mainly in the (sub) tropics,
where it causes dengue fever and/or the more serious diseases dengue hemorrhagic fever …

The prognosis of dengue remains a challenge in the early, objective triage of patients with
dengue fever of differing severity. Circulating immuno-modulating proteins have brought …