Functional hydrogels for the treatment of myocardial infarction

T Wu, W Liu - NPG Asia Materials, 2022 - nature.com
Myocardial infarction (MI) is a major disease posing a significant threat to human health, as it
leads to necrosis of numerous cardiomyocytes (CMs), left ventricle dilation, and cardiac …

Biodegradable polymers as the pivotal player in the design of tissue engineering scaffolds

F Zhang, MW King - Advanced healthcare materials, 2020 - Wiley Online Library
Biodegradable polymers play a pivotal role in in situ tissue engineering. Utilizing various
technologies, researchers have been able to fabricate 3D tissue engineering scaffolds using …

A multi-cellular 3D bioprinting approach for vascularized heart tissue engineering based on HUVECs and iPSC-derived cardiomyocytes

F Maiullari, M Costantini, M Milan, V Pace, M Chirivì… - Scientific reports, 2018 - nature.com
The myocardium behaves like a sophisticated orchestra that expresses its true potential only
if each member performs the correct task harmonically. Recapitulating its complexity within …

Coadministration of an adhesive conductive hydrogel patch and an injectable hydrogel to treat myocardial infarction

T Wu, C Cui, Y Huang, Y Liu, C Fan… - … applied materials & …, 2019 - ACS Publications
Over the past decade, tissue-engineering strategies, mainly involving injectable hydrogels
and epicardial biomaterial patches, have been pursued to treat myocardial infarction …

An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs

K Huang, EW Ozpinar, T Su, J Tang, D Shen… - Science translational …, 2020 - science.org
Cell therapy has been a promising strategy for cardiac repair after injury or infarction;
however, low retention and engraftment of transplanted cells limit potential therapeutic …

[HTML][HTML] An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair

L Zhang, T Li, Y Yu, K Shi, Z Bei, Y Qian, Z Qian - Bioactive Materials, 2023 - Elsevier
Myocardial infarction (MI) leads to massive cardiomyocyte death and deposition of collagen
fibers. This fibrous tissue disrupts electrical signaling in the myocardium, leading to cardiac …

A tunable self-healing ionic hydrogel with microscopic homogeneous conductivity as a cardiac patch for myocardial infarction repair

X Song, X Wang, J Zhang, S Shen, W Yin, G Ye… - Biomaterials, 2021 - Elsevier
Conductive hydrogel is a potential therapeutic tool to treat damaged heart muscles in
myocardial infarction (MI). However, it is still a quite challenge to optimize the fabrication of a …

3D cardiac cell culture: a critical review of current technologies and applications

C Zuppinger - Frontiers in cardiovascular medicine, 2019 - frontiersin.org
Three-dimensional (3D) cell culture is often mentioned in the context of regenerative
medicine, for example, for the replacement of ischemic myocardium with tissue-engineered …

Robust anisotropic cellulose hydrogels fabricated via strong self-aggregation forces for cardiomyocytes unidirectional growth

D Ye, P Yang, X Lei, D Zhang, L Li, C Chang… - Chemistry of …, 2018 - ACS Publications
The development of a facile and fast method to construct anisotropic hydrogels with the
ability to induce unidirectional growth of cells remains challenging. In this work, we …

Current applications of polycaprolactone as a scaffold material for heart regeneration

PR Schmitt, KD Dwyer… - ACS Applied Bio Materials, 2022 - ACS Publications
Despite numerous advances in treatments for cardiovascular disease, heart failure (HF)
remains the leading cause of death worldwide. A significant factor contributing to the …