The molecular mechanism of natural killer cells function and its importance in cancer immunotherapy

S Paul, G Lal - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …

Balancing natural killer cell activation through paired receptors

L Martinet, MJ Smyth - Nature Reviews Immunology, 2015 - nature.com
Natural killer (NK) cells are innate lymphocytes that are crucial for the control of infections
and malignancies. NK cells express a variety of inhibitory and activating receptors that …

Controlling natural killer cell responses: integration of signals for activation and inhibition

EO Long, H Sik Kim, D Liu, ME Peterson… - Annual review of …, 2013 - annualreviews.org
Understanding how signals are integrated to control natural killer (NK) cell responsiveness
in the absence of antigen-specific receptors has been a challenge, but recent work has …

Natural killer cell cytotoxicity and its regulation by inhibitory receptors

S Kumar - Immunology, 2018 - Wiley Online Library
Natural killer (NK) cells express an array of germ‐line encoded receptors that are capable of
triggering cytotoxicity. NK cells tend to express many members of a given family of signalling …

[HTML][HTML] NK cell-based tumor immunotherapy

H Zhang, L Yang, T Wang, Z Li - Bioactive materials, 2024 - Elsevier
Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-
infected cells and tumor cells. They are particularly powerful for elimination of hematological …

NK cell recognition

LL Lanier - Annu. Rev. Immunol., 2005 - annualreviews.org
NK CELL RECOGNITION | Annual Reviews Menu Publications AZ Journal Information About
Subscribe Give Personal Register/Sign-in 0 Cart Help Journal Information Author Resource …

Up on the tightrope: natural killer cell activation and inhibition

LL Lanier - Nature immunology, 2008 - nature.com
Natural killer (NK) cells circulate through the blood, lymphatics and tissues, on patrol for the
presence of transformed or pathogen-infected cells. As almost all NK cell receptors bind to …

Formation and function of the lytic NK-cell immunological synapse

JS Orange - Nature Reviews Immunology, 2008 - nature.com
The natural killer (NK)-cell immunological synapse is the dynamic interface formed between
an NK cell and its target cell. Formation of the NK-cell immunological synapse involves …

Activation, coactivation, and costimulation of resting human natural killer cells

YT Bryceson, ME March, HG Ljunggren… - Immunological …, 2006 - Wiley Online Library
Natural killer (NK) cells possess potent perforin‐and interferon‐γ‐dependent effector
functions that are tightly regulated. Inhibitory receptors for major histocompatibility complex …

SLAM family receptors and SAP adaptors in immunity

JL Cannons, SG Tangye… - Annual review of …, 2011 - annualreviews.org
The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first
identified as the protein affected in most cases of X-linked lymphoproliferative (XLP) …