Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

Autophagy is a cellular homeostasis mechanism that fuels the proliferation and survival of
advanced cancers by degrading and recycling organelles and proteins. Preclinical studies …

Positive-strand RNA viruses replicate in close association with rearranged intracellular
membranes. For hepatitis C virus (HCV) and severe acute respiratory syndrome coronavirus …

Targeting autophagy in cancer cells and in the tumor microenvironment are current goals of
cancer therapy. However, components of canonical autophagy play roles in other biological …

Autophagy is best known for its role in organelle and protein turnover, cell quality control,
and metabolism. The autophagic machinery has, however, also adapted to enable protein …

Alzheimer's disease (AD) is the most common type of dementia affecting regions of the
central nervous system that exhibit synaptic plasticity and are involved in higher brain …

The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …

Autophagy and glycolysis are highly conserved biological processes involved in both
physiological and pathological cellular programs, but the interplay between these processes …

Autophagy is a process through which intracellular cargoes are catabolised inside
lysosomes. It involves the formation of autophagosomes initiated by the serine/threonine …

The endolysosomal system fulfils a myriad of cellular functions predicated on regulated
membrane identity progressions, collectively termed maturation. Mature or “late” endosomes …