Acute decompensation of chronic heart failure is a direct life‐threatening situation with short‐
term mortality approaching 30%. A number of maladaptive changes are amplified within the …

Introduction: In the 20 years since its introduction to the palette of intravenous hemodynamic
therapies, the inodilator levosimendan has established itself as a valuable asset for the …

Objective Calcium desensitization plays an important part in the pathophysiology of septic
myocardial depression. We postulated that levosimendan, a new calcium sensitizer, would …

PDE4 isoenzymes are critical in the control of cAMP signaling in rodent cardiac myocytes.
Ablation of PDE4 affects multiple key players in excitation–contraction coupling and …

INTRODUCTION AND OBJECTIVES: The use of levosimendan to treat postoperative low
cardiac output syndrome (LCOS) has been studied in only small patient series and in …

Levosimendan (up to 10 µM) given alone failed to increase force of contraction in isolated
electrically stimulated (1 Hz) left atrial (LA) preparations from wild-type mice. Only in the …

Platelet aggregation is a crucial feature in coronary artery thrombus formation and is a major
causative factor in both acute coronary syndromes (ACS) and reocclusion after …

We investigated both the effect of levosimendan and the role of various potassium channels
in KCl-precontracted rat small mesenteric arteries. Levosimendan (10− 6− 10− 3 M) or …

This study investigates the role of the mitochondrial ATP-sensitive K+ channel (mitoKATP) in
response to positive inotropic stress. In Langendorff-perfused rat hearts, inotropy was …

Levosimendan is emerging as a novel cardioprotective inotrope. Levosimendan augments
myocardial contractility by sensitising contractile myofilaments to calcium without increasing …