Hematopoiesis involves an elaborate regulatory network of transcription factors that
coordinates the expression of multiple downstream genes, and maintains homeostasis …

The correct maintenance and differentiation of hematopoietic stem cells (HSC) in bone
marrow is vital for the maintenance and operation of the human blood system. GATA2 plays …

The transcription factor Runx1/AML1 is an important regulator of hematopoiesis and is
critically required for the generation of the first definitive hematopoietic stem cells (HSCs) in …

During early mammalian development, genesis of the first two cell lineages, inner cell mass
(ICM) and trophectoderm (TE), is dependent upon functions of key transcription factors that …

Combinatorial actions of relatively few transcription factors control hematopoietic
differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the …

The raphe nuclei represent the origin of central serotonergic projections. The literature
distinguishes seven nuclei grouped into rostral and caudal clusters relative to the pons. The …

The transcription factor Gata1 is expressed in several hematopoietic lineages and plays
essential roles in normal hematopoietic development during embryonic stages. The lethality …

Strict regulations of the Gata1 and Gata2 genes are critical for proper lineage commitment
and development of erythroid cells. It has been shown in transgenic mouse analyses that cis …

Constitutive activation of the canonical NF-κB pathway has been associated with a variety of
human pathologies. However, molecular mechanisms through which canonical NF-κB …

Histology refers to the study of the morphology of cells within their natural tissue
environment. As a bio‐medical discipline, it dates back to the development of first …