Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haemopoietic
progenitor cells and the most common malignant myeloid disorder in adults. The median …

Acute myeloid leukemia (AML) is the most common acute leukemia in adults that affects the
myeloid lineage. The recent advances have upgraded our understanding of the cytogenetic …

Acute myeloid leukemia (AML) comprises a heterogeneous group of leukemias frequently
defined by recurrent cytogenetic abnormalities, including rearrangements involving the core …

To evaluate the prognostic value of genetic mutations for acute myeloid leukemia (AML)
patients, we examined the gene status for both fusion products such as AML1 (CBF α)–ETO …

Abstract NF-E2–related factor 2 (Nrf2) transcription factor regulates a range of cytoprotective
transcriptional responses, preventing further cellular injury by removing biochemical …

Mutations in the nucleophosmin 1 (NPM1) gene are considered a founder event in the
pathogenesis of acute myeloid leukemia (AML). To address the role of clonal evolution in …

An alternative to therapeutic targeting of oncogenes is to perform" synthetic lethality" screens
for genes that are essential only in the context of specific cancer-causing mutations. We …

Acute myeloid leukemia (AML) is a heterogeneous group of neoplastic disorders with great
variability in clinical course and response to therapy, as well as in the genetic and molecular …

In core binding factors (CBF) acute myeloid leukemia (AML), the disruption of CBFα/β genes
impairs normal hematopoietic differentiation and is supposed to cooperate with additional …

The prognostic impact of tyrosine kinase domain (TKD) mutations of the fms-like tyrosine
kinase-3 (FLT3) gene in acute myeloid leukemia (AML) is currently uncertain. To resolve this …