Synopsis The DNA polymerase of human herpes viruses, including cytomegalovirus (CMV),
and the reverse transcriptase of human immunodeficiency virus (HIV) are selectively …

Synopsis The pyrophosphate analogue, foscarnet, selectively inhibits the DNA polymerase
of human herpes viruses, including cytomegalovirus, and the reverse transcriptase of HIV …

OBJECTIVE: To evaluate the frequency of ocular complications and the clinical outcomes of
these complications in patients with various stages of HIV infection. METHODS …

Background Sustained-release, intraocular implants that deliver ganciclovir are an
alternative method for the treatment of cytomegalovirus retinitis in patients with the acquired …

Background and Methods: We performed a randomized controlled clinical trial to assess the
safety and efficacy of a 1 μg/h ganciclovir implant for the treatment of newly diagnosed …

▪ Objective: To evaluate foscarnet sodium in treating cytomegalovirus retinitis in patients with
AIDS.▪ Patients: Twenty-four previously untreated persons with AIDS and cytomegalovirus …

Background Cytomegalovirus retinitis, a sight-threatening infection associated with the
acquired immunodeficiency syndrome (AIDS), currently requires lifelong intravenous …

The ocular posterior segment manifestations of AIDS may be divided into four categories:
retinal vasculopathy, unusual malignancies, neuro-ophthalmologic abnormalities, and …

• Retinal detachments are a recognized complication of cytomegalovirus retinitis. In a series
of 145 patients with cytomegalovirus retinitis, 38 (26%) developed retinal detachments. The …

Drugs capable of inhibiting viruses in vitro were described in the 1950s, but real progress
was not made until the 1970s, when agents capable of inhibiting virus-specific enzymes …