Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments
L Zuo, ER Prather, M Stetskiv, DE Garrison… - International journal of …, 2019 - mdpi.com
It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …
inflammaging, is implicated in multiple disease states commonly observed in the elderly …
Diabetes, metabolic disease, and telomere length
Telomeres are regions of repetitive nucleotide sequences at the ends of chromosomes.
Telomere length is a marker of DNA damage, which is often considered a biomarker for …
Telomere length is a marker of DNA damage, which is often considered a biomarker for …
[HTML][HTML] Ageing as a risk factor for disease
T Niccoli, L Partridge - Current biology, 2012 - cell.com
Age is the main risk factor for the prevalent diseases of developed countries: cancer,
cardiovascular disease and neurodegeneration. The ageing process is deleterious for …
cardiovascular disease and neurodegeneration. The ageing process is deleterious for …
Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
N Kubben, T Misteli - Nature Reviews Molecular Cell Biology, 2017 - nature.com
Ageing is the predominant risk factor for many common diseases. Human premature ageing
diseases are powerful model systems to identify and characterize cellular mechanisms that …
diseases are powerful model systems to identify and characterize cellular mechanisms that …
Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall
C Werner, T Fürster, T Widmann, J Pöss, C Roggia… - Circulation, 2009 - Am Heart Assoc
Background—The underlying molecular mechanisms of the vasculoprotective effects of
physical exercise are incompletely understood. Telomere erosion is a central component of …
physical exercise are incompletely understood. Telomere erosion is a central component of …
Is telomere length a biomarker of aging? A review
Telomeres, the DNA–protein structures located at the ends of chromosomes, have been
proposed to act as a biomarker of aging. In this review, the human evidence that telomere …
proposed to act as a biomarker of aging. In this review, the human evidence that telomere …
Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress-preliminary findings
Background Depression is associated with an unusually high rate of aging-related illnesses
and early mortality. One aspect of “accelerated aging” in depression may be shortened …
and early mortality. One aspect of “accelerated aging” in depression may be shortened …
Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease
Context Increased dietary intake of marine omega-3 fatty acids is associated with prolonged
survival in patients with coronary heart disease. However, the mechanisms underlying this …
survival in patients with coronary heart disease. However, the mechanisms underlying this …
Effects of aging on angiogenesis
J Lähteenvuo, A Rosenzweig - Circulation research, 2012 - Am Heart Assoc
Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired
angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of …
angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of …
Vascular endothelial senescence: from mechanisms to pathophysiology
JD Erusalimsky - Journal of Applied Physiology, 2009 - journals.physiology.org
Most mitotically competent mammalian cell types can react to stress by undergoing a
phenotypically distinctive and permanent form of growth arrest called “cellular senescence.” …
phenotypically distinctive and permanent form of growth arrest called “cellular senescence.” …