It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …

Telomeres are regions of repetitive nucleotide sequences at the ends of chromosomes.
Telomere length is a marker of DNA damage, which is often considered a biomarker for …

Age is the main risk factor for the prevalent diseases of developed countries: cancer,
cardiovascular disease and neurodegeneration. The ageing process is deleterious for …

Ageing is the predominant risk factor for many common diseases. Human premature ageing
diseases are powerful model systems to identify and characterize cellular mechanisms that …

Background—The underlying molecular mechanisms of the vasculoprotective effects of
physical exercise are incompletely understood. Telomere erosion is a central component of …

Telomeres, the DNA–protein structures located at the ends of chromosomes, have been
proposed to act as a biomarker of aging. In this review, the human evidence that telomere …

Background Depression is associated with an unusually high rate of aging-related illnesses
and early mortality. One aspect of “accelerated aging” in depression may be shortened …

Context Increased dietary intake of marine omega-3 fatty acids is associated with prolonged
survival in patients with coronary heart disease. However, the mechanisms underlying this …

Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired
angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of …

Most mitotically competent mammalian cell types can react to stress by undergoing a
phenotypically distinctive and permanent form of growth arrest called “cellular senescence.” …