[HTML][HTML] Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease

G Marucci, M Buccioni, D Dal Ben, C Lambertucci… - …, 2021 - Elsevier
Abstract Alzheimer's disease (AD), the most common cause of adult-onset dementia is
characterized by a progressive decline of cognitive functions accompanied by behavioral …

A review on advances of treatment modalities for Alzheimer's disease

ES Thoe, A Fauzi, YQ Tang, S Chamyuang, AYY Chia - Life sciences, 2021 - Elsevier
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which is mainly
characterized by progressive impairment in cognition, emotion, language and memory in …

Screening for cognitive impairment in older adults: a systematic review for the US Preventive Services Task Force

JS Lin, E O'Connor, RC Rossom… - Annals of internal …, 2013 - acpjournals.org
This article has been corrected. The original version (PDF) is appended to this article as a
supplement. Background: Earlier identification of cognitive impairment may reduce patient …

Rivastigmine for Alzheimer's disease

JS Birks, JG Evans - Cochrane Database of systematic …, 2015 - cochranelibrary.com
Background Alzheimer's disease is the commonest cause of dementia affecting older
people. One of the therapeutic strategies aimed at ameliorating the clinical manifestations of …

Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline

P Raina, P Santaguida, A Ismaila… - Annals of internal …, 2008 - acpjournals.org
Background: The effectiveness of the 5 US Food and Drug Administration–approved
pharmacologic therapies for dementias in achieving clinically relevant improvements is …

Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson's …

N Kandiah, MC Pai, V Senanarong, I Looi… - … interventions in aging, 2017 - Taylor & Francis
Several studies have demonstrated clinical benefits of sustained cholinesterase inhibition
with rivastigmine in Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) …

Alzheimer's disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies

DS Auld, TJ Kornecook, S Bastianetto… - Progress in neurobiology, 2002 - Elsevier
Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

Targeting acetylcholinesterase and butyrylcholinesterase in dementia

RM Lane, SG Potkin, A Enz - International Journal of …, 2006 - academic.oup.com
Abstract The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying
the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain …

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

MH Tuszynski, L Thal, M Pay, DP Salmon, HS U… - Nature medicine, 2005 - nature.com
Cholinergic neuron loss is a cardinal feature of Alzheimer disease. Nerve growth factor
(NGF) stimulates cholinergic function, improves memory and prevents cholinergic …

Core candidate neurochemical and imaging biomarkers of Alzheimer's disease

H Hampel, K Bürger, SJ Teipel, ALW Bokde… - Alzheimer's & …, 2008 - Elsevier
BACKGROUND: In the earliest clinical stages of Alzheimer's disease (AD) when symptoms
are mild, clinical diagnosis can be difficult. AD pathology most likely precedes symptoms …