Metabolic syndrome is co-occurrence of obesity, insulin resistance, atherogenic
dyslipidemia (high triglyceride, low high density lipoprotein cholesterol), and hypertension. It …

Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and
obesity associated (FTO) gene are associated obesity traits in genome-wide association …

Admixed populations are routinely excluded from genomic studies due to concerns over
population structure. Here, we present a statistical framework and software package, Tractor …

Insulin resistance and the metabolic syndrome are complex metabolic traits and key risk
factors for the development of cardiovascular disease. They result from the interplay of …

Advances in genotyping technology have, over the past decade, enabled the focused
search for common genetic variation associated with human diseases and traits. With the …

Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were
largely unknown, with the exception of a few forms of monogenic extreme obesity. Since …

Many human traits are highly correlated. This correlation can be leveraged to improve the
power of genetic association tests to identify markers associated with one or more of the …

We hypothesize that imputation based on data from the 1000 Genomes Project can identify
novel association signals on a genome-wide scale due to the dense marker map and the …

Metabolic syndrome (MetS) is a cluster of metabolic traits associated with an increased risk
of cardiovascular disease and type 2 diabetes mellitus. Central obesity and insulin …

To achieve sensitive and specific mechanism-based prediction of drug toxicity, the tools of
systems pharmacology will be integrated using structured ontological approaches, analytics …