GABAA receptors: structure, function, pharmacology, and related disorders
Background γ-Aminobutyric acid sub-type A receptors (GABAARs) are the most prominent
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …
The role of GABA in islet function
Gamma aminobutyric acid (GABA) is a non-proteinogenic amino acid and neurotransmitter
that is produced in the islet at levels as high as in the brain. GABA is synthesized by the …
that is produced in the islet at levels as high as in the brain. GABA is synthesized by the …
The GABA and GABA-receptor system in inflammation, anti-tumor immune responses, and COVID-19
J Tian, DL Kaufman - Biomedicines, 2023 - mdpi.com
GABA and GABAA-receptors (GABAA-Rs) play major roles in neurodevelopment and
neurotransmission in the central nervous system (CNS). There has been a growing …
neurotransmission in the central nervous system (CNS). There has been a growing …
[HTML][HTML] The potential role of pancreatic γ-aminobutyric acid (GABA) in diabetes mellitus: a critical reappraisal
HM Al-Kuraishy, NR Hussian, MS Al-Naimi… - … Journal of Preventive …, 2021 - ncbi.nlm.nih.gov
Background: Diabetes mellitus (DM) is an endocrine disorder characterized by
hyperglycemia, polyuria, polydipsia, and glucosuria. γ-aminobutyric acid (GABA) is an …
hyperglycemia, polyuria, polydipsia, and glucosuria. γ-aminobutyric acid (GABA) is an …
Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell
Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (γ-aminobutyric
acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet …
acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet …
Gamma-aminobutyric acid (GABA)-mediated bone formation and its implications for anti-osteoporosis strategies: Exploring the relation between GABA and GABA …
WAHM Karunarathne, YH Choi, MH Lee… - Biochemical …, 2023 - Elsevier
Osteoporosis is a significant global health concern, linked to reduced bone density and an
increased fracture risk, with effective treatments still lacking. This study explored the …
increased fracture risk, with effective treatments still lacking. This study explored the …
Ion channels of the islets in type 2 diabetes
DA Jacobson, SL Shyng - Journal of molecular biology, 2020 - Elsevier
Ca 2+ is an essential signal for pancreatic β-cell function. Ca 2+ plays critical roles in
numerous β-cell pathways such as insulin secretion, transcription, metabolism, endoplasmic …
numerous β-cell pathways such as insulin secretion, transcription, metabolism, endoplasmic …
GABA promotes β‐cell proliferation, but does not overcome impaired glucose homeostasis associated with diet‐induced obesity
A Untereiner, S Abdo, A Bhattacharjee… - The FASEB …, 2019 - Wiley Online Library
ABSTRACT γ‐Aminobutyric acid (GABA) administration has been shown to increase β‐cell
mass, leading to a reversal of type 1 diabetes in mice. Whether GABA has any effect on β …
mass, leading to a reversal of type 1 diabetes in mice. Whether GABA has any effect on β …
ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetes
Impaired insulin secretion from pancreatic islets is a hallmark of type 2 diabetes (T2D).
Altered chromatin structure may contribute to the disease. We therefore studied the impact of …
Altered chromatin structure may contribute to the disease. We therefore studied the impact of …
Development of Janus particles as potential drug delivery systems for diabetes treatment and antimicrobial applications
Janus particles have emerged as a novel and smart material that could improve
pharmaceutical formulation, drug delivery, and theranostics. Janus particles have two …
pharmaceutical formulation, drug delivery, and theranostics. Janus particles have two …