The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …

Abstract Protein Tyrosine Phosphatase 1B (PTP1B), as one of the most important members
in PTP superfamily, plays a vital role in conducting various cellular functions. So far, PTP1B …

The tetrazole ring is an important pharmacophore. It is a structural component in many
drugs, drug candidates (or lead compounds) and various biochemical reagents. This review …

Lead optimization represents the tedious process of fine‐tuning lead compounds from
biologically active hits to suitable drug candidates for clinical trials. By chemically modifying …

Background: There has been growing interest in the development of highly potent and
selective protein tyrosine phosphatase (PTP1B) inhibitors for the past 2-3 decades. Though …

Diabetes mellitus (DM), especially type 2 diabetes mellitus (T2DM), is the most disruptive
metabolic disorder globally affecting human health. To effectively manage this medical …

Diabetes mellitus (DM) is a serious global health concern affecting over 500 million people.
To put it simply, it is one of the most dangerous metabolic illnesses. Insulin resistance is the …

Four series of berberine derivatives were designed and synthesized. All the synthetic
compounds were screened for in vitro glucose consumption activity in HepG2 cell lines. The …

A series of ten N-(3-(1H-tetrazole-5-yl) phenyl) acetamide derivatives (NM-07 to NM-16)
designed from a lead molecule identified previously in our laboratory were synthesized and …

Protein tyrosine phosphatase 1B (PTP1B), a key negative regulator of insulin signaling, is
considered as a promising and validated therapeutic target for type 2 diabetes mellitus …