Overview of MMP-13 as a promising target for the treatment of osteoarthritis

Q Hu, M Ecker - International journal of molecular sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of
articular cartilage and chronic inflammation of surrounding tissues. Matrix metalloproteinase …

Cartilage regeneration and ageing: targeting cellular plasticity in osteoarthritis

M Varela-Eirin, J Loureiro, E Fonseca… - Ageing research …, 2018 - Elsevier
Ageing processes play a major contributing role for the development of Osteoarthritis (OA).
This prototypic degenerative condition of ageing is the most common form of arthritis and is …

[Retracted] Healthcare and Scientific Treatment of Knee Osteoarthritis

H Wang, B Ma - Journal of Healthcare Engineering, 2022 - Wiley Online Library
Knee osteoarthritis is a chronic degenerative disease companied with chronic knee pain
and dysfunction. However, the etiology and pathogenesis of knee osteoarthritis were …

Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis

Y Wei, L Bai - Connective tissue research, 2016 - Taylor & Francis
Osteoarthritis (OA), the most common form of degenerative joint disease, is linked to high
morbidity. It is predicted to be the single greatest cause of disability in the general population …

Toll-like receptor 2 induced senescence in intervertebral disc cells of patients with back pain can be attenuated by o-vanillin

M Mannarino, H Cherif, L Li, K Sheng, O Rabau… - Arthritis research & …, 2021 - Springer
Background There is an increased level of senescent cells and toll-like teceptor-1,-2,-4, and-
6 (TLR) expression in degenerating intervertebral discs (IVDs) from back pain patients …

Activation of the phosphatidylcholine to lysophosphatidylcholine pathway is associated with osteoarthritis knee cartilage volume loss over time

G Zhai, JP Pelletier, M Liu, D Aitken, E Randell… - Scientific reports, 2019 - nature.com
To identify serum biomarker (s) for predicting knee cartilage volume loss over time, we
studied 139 knee osteoarthritis (OA) patients from a previous 24-month clinical trial cohort …

Polyurethane scaffold with in situ swelling capacity for nucleus pulposus replacement

Z Li, G Lang, X Chen, H Sacks, C Mantzur, U Tropp… - Biomaterials, 2016 - Elsevier
Nucleus pulposus (NP) replacement offers a minimally invasive alternative to spinal fusion
or total disc replacement for the treatment of intervertebral disc (IVD) degeneration. This …

Aberrant activation of latent transforming growth factor-β initiates the onset of temporomandibular joint osteoarthritis

L Zheng, C Pi, J Zhang, Y Fan, C Cui, Y Zhou, J Sun… - Bone research, 2018 - nature.com
There is currently no effective medical treatment for temporomandibular joint osteoarthritis
(TMJ-OA) due to a limited understanding of its pathogenesis. This study was undertaken to …

Roles of TGF-beta 1 signaling in the development of osteoarthritis

J Fang, L Xu, Y Li, Z Zhao - 2016 - digitum.um.es
Osteoarthritis (OA) is a degenerative joint disorder characterized by the destruction of
articular cartilage, subchondral bone and other joint tissues. Although multiple growth …

Gut-microbiota modulation: the impact of the gut-microbiota on osteoarthritis

V Arora, G Singh, O InSug, K Ma, AN Anbazhagan… - Gene, 2021 - Elsevier
Osteoarthritis (OA) is one of the most common medical conditions affecting> 300 million
people globally which represents the formidable public health challenge. Despite its clinical …