The casein kinase 1 enzymes (CK1) form a family of serine/threonine kinases with seven
CK1 isoforms identified in humans. The most important substrates of CK1 kinases are …

Simple Summary Immunomodulatory drugs (IMiDs) are effective in the treatment of multiple
myeloma (MM) and other hematological malignancies. Cereblon (CRBN), a target of IMiDs …

Hypertensive renal injury is a complication of hypertension. Cordyceps cicadae (C. cicadae)
is a traditional Chinese medicine used to treat chronic kidney diseases especially renal …

Abstract Adjuvant chemotherapy with 5-fluorouracil (5-FU) does not improve survival of
patients suffering from a form of colorectal cancer (CRC) characterized by high level of …

Highlights•IMID's molecular mechanism explain their efficacy in hematological
malignancies.•Lenalidomide-treated patients become resistant through cancer-specific …

Disturbance of protein kinase activity may result in dramatic consequences that often lead to
cancer development and progression. In tumors of blood origin, both tyrosine kinases and …

Enhancement of autophagy serves as a promising therapeutic strategy for cancer, including
acute myeloid leukemia (AML). Casein kinase 1α (CK1α), encoded by CSNK1A1, regulates …

Motivation Gaining a comprehensive understanding of the genetics underlying cancer
development and progression is a central goal of biomedical research. Its accomplishment …

The Wnt/β-catenin pathway, which interferes with cell proliferation, differentiation, and
autophagy, is commonly dysregulated in colorectal cancer (CRC). Mutation of the RAS …

Activation of autophagy plays a critical role in DNA repair, especially for the process of
homologous recombination. Despite upregulation of autophagy promotes both the survival …