Epoxide hydrolases (EH), enzymes present in all living organisms, transform epoxide-
containing lipids to 1, 2-diols by the addition of a molecule of water. Many of these …

Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen with multiple niches in the
human body, including the lung. P. aeruginosa infections are particularly damaging or fatal …

Recurrent Pseudomonas aeruginosa infections coupled with robust, damaging neutrophilic
inflammation characterize the chronic lung disease cystic fibrosis (CF). The proresolving …

Alpha/beta hydrolases function as hydrolases, lyases, transferases, hormone precursors or
transporters, chaperones or routers of other proteins. The amount of structural and functional …

Genes coding for members of the alpha/beta hydrolase fold superfamily of proteins are
present in all known genomes. Although there is no common and essential function …

The cytochrome P450s (CYPs) represent a highly divergent class of enzymes involved in the
oxidation of organic compounds. A subgroup of CYPs metabolize ω3-arachidonic and …

Haloalkane dehalogenases and epoxide hydrolases are phylogenetically related and
structurally homologous enzymes that use nucleophilic aspartate residues for an SN2 attack …

Lead identification and optimization are essential steps in the development of a new drug. It
requires cost-effective, selective and sensitive chemical tools. Here, we report a novel …

The virulence factor cystic fibrosis transmembrane conductance regulator (CFTR) inhibitory
factor (Cif) is secreted by Pseudomonas aeruginosa and is the founding member of a distinct …

Epoxide hydrolases (EHs), which catalyze the transformation of epoxides to diols, are
present in many eukaryotic and prokaryotic organisms. They have recently drawn …