Sirtuins are a family of NAD+-dependent deacylases with numerous physiological and
pathological implications, which lately became an attractive therapeutic target. Sirtuin …

Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins
(SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial …

The essential oils extracted from Pistacia lentiscus resins possess promising antiproliferative
effects against ovarian and breast cancer cells because of their high content of bioactive …

Highlights•SIRT3, a major deacetylase in mitochondria, regulates almost every aspect of
mitochondrial health and functionality.•SIRT3 controls vital functions like energy balance …

Background Hypertension has seriously affected a large part of the adult and elderly
population. The complications caused by hypertension are important risk factors for …

Chronic arsenic (As) exposure, mainly as a result of drinking contaminated water, is
associated with cardiovascular diseases. Mitochondrial dysfunction, oxidative stress …

Hepatic encephalopathy (HE) is a serious neurological disorder which might occur in both
acute and chronic liver injury. Aims: This study was carried out to explore the protective …

Cardiovascular diseases (CVDs) are currently the most common cause of morbidity and
mortality worldwide. Experimental studies suggest that liver kinase B1 (LKB1) plays an …

Doxorubicin is a potent chemotherapeutic agent that can cause cardiotoxicity. Many
documents (more than 14,000) have been published in the area of doxorubicin-induced …

Doxorubicin (DOX) is a highly effective chemotherapeutic drug, but its long-term use can
cause cardiotoxicity and drug resistance. Accumulating evidence demonstrates that p53 is …