Beyond E-cadherin: roles of other cadherin superfamily members in cancer

F Van Roy - Nature Reviews Cancer, 2014 - nature.com
Abstract Loss of cadherin 1 (CDH1; also known as epithelial cadherin (E-cadherin)) is used
for the diagnosis and prognosis of epithelial cancers. However, it should not be ignored that …

[HTML][HTML] Targeting tumour microenvironment by tyrosine kinase inhibitor

HY Tan, N Wang, W Lam, W Guo, Y Feng, YC Cheng - Molecular cancer, 2018 - Springer
Tumour microenvironment (TME) is a key determinant of tumour growth and metastasis.
TME could be very different for each type and location of tumour and TME may change …

[HTML][HTML] Garcinol exerts anti-cancer effect in human cervical cancer cells through upregulation of T-cadherin

J Zhao, T Yang, J Ji, C Li, Z Li, L Li - Biomedicine & pharmacotherapy, 2018 - Elsevier
Garcinol, a polyisoprenylated benzophenone, has been demonstrated to exert anti-cancer
effects in various tumor cells. However, the effect of garcinol on cervical cancer (CC) cell …

[HTML][HTML] Cadherin 13 inhibits pancreatic cancer progression and epithelial-mesenchymal transition by Wnt/β-catenin signaling

D Xu, H Yuan, Z Meng, C Yang, Z Li, M Li… - Journal of …, 2020 - ncbi.nlm.nih.gov
Abstract Cadherin 13 (CDH13) is an atypical cadherin that exerts tumor-suppressive effects
on cancers derived from epithelial cells. Although the CDH13 promoter is frequently …

Overexpression of T-cadherin inhibits the proliferation of oral squamous cell carcinoma through the PI3K/AKT/mTOR intracellular signalling pathway

Q Wang, X Zhang, X Song, L Zhang - Archives of oral biology, 2018 - Elsevier
Objective To evaluate T-cadherin gene expression in patients with oral squamous cell
carcinoma (OSCC) and explore its effect on the proliferation of OSCC. Additionally, the …

EGFR and IGF‐1R in regulation of prostate cancer cell phenotype and polarity: opposing functions and modulation by T‐cadherin

K Maslova, E Kyriakakis, D Pfaff, A Frachet… - The Faseb …, 2015 - Wiley Online Library
ABSTRACT T‐cadherin is an atypical glycosylphosphatidylinsoitol‐anchored member of the
cadherin superfamily of adhesion molecules. We found that T‐cadherin over‐expression in …

Density-dependent ERK MAPK expression regulates MMP-9 and influences growth

V Marchese, J Juarez, P Patel… - Molecular and cellular …, 2019 - Springer
Previous work has shown that expression of the extracellular signal-regulated kinase (ERK)
is decreased by high density in normal fibroblast cells, and this was correlated with …

[HTML][HTML] Association between the expression of T-cadherin and vascular endothelial growth factor and the prognosis of patients with gastric cancer

B Wei, H Shi, X Lu, A Shi… - Molecular medicine …, 2015 - spandidos-publications.com
T-cadherin has been identified as a tumor-suppressor gene in several types of cancer. The
present study aimed to investigate the association of the expression of T-cadherin with …

T‐cadherin in prostate cancer: relationship with cancer progression, differentiation and drug resistance

B Dasen, T Vlajnic, C Mengus, C Ruiz… - The Journal of …, 2017 - Wiley Online Library
Prostate cancer represents the second leading cause of cancer‐related death in men. T‐
cadherin (CDH13) is an atypical GPI‐anchored member of the cadherin family of adhesion …

The functional roles of T-cadherin in mammalian biology

J Sternberg, M Wankell, VN Subramaniam… - AIMS Molecular …, 2017 - eprints.qut.edu.au
T-cadherin is a cadherin and cell adhesion molecule that is anchored to the cell surface
membrane through a glycosylphosphatidylinositol moiety. T-cadherin lacks a …