The recombinase activating genes: architects of immune diversity during lymphocyte development
M Braams, K Pike-Overzet, FJT Staal - Frontiers in Immunology, 2023 - frontiersin.org
The mature lymphocyte population of a healthy individual has the remarkable ability to
recognise an immense variety of antigens. Instead of encoding a unique gene for each …
recognise an immense variety of antigens. Instead of encoding a unique gene for each …
V (D) J recombination: recent insights in formation of the recombinase complex and recruitment of DNA repair machinery
SM Christie, C Fijen, E Rothenberg - Frontiers in Cell and …, 2022 - frontiersin.org
V (D) J recombination is an essential mechanism of the adaptive immune system, producing
a diverse set of antigen receptors in developing lymphocytes via regulated double strand …
a diverse set of antigen receptors in developing lymphocytes via regulated double strand …
Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time
Advances in DNA sequencing have revolutionized our ability to read genomes. However,
even in the most well-studied of organisms, the bacterium Escherichia coli, for≈ 65% of …
even in the most well-studied of organisms, the bacterium Escherichia coli, for≈ 65% of …
Molecular mechanisms of DNA sequence selectivity in V (D) J recombination
W Hoolehan, JC Harris, KK Rodgers - ACS omega, 2023 - ACS Publications
Antigen receptor (AgR) diversity is central to the ability of adaptive immunity in jawed
vertebrates to protect against pathogenic agents. The production of highly diverse AgR …
vertebrates to protect against pathogenic agents. The production of highly diverse AgR …
RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V (D) J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia
X Yu, W Zhou, X Chen, S He, M Qin, M Yuan, Y Wang… - eLife, 2024 - elifesciences.org
The evolutionary conservation of non-core RAG regions suggests significant roles that might
involve quantitative or qualitative alterations in RAG activity. Off-target V (D) J recombination …
involve quantitative or qualitative alterations in RAG activity. Off-target V (D) J recombination …
The usage of human IGHJ genes follows a particular non-random selection: the recombination signal sequence may affect the usage of human IGHJ genes
B Shi, X Dong, Q Ma, S Sun, L Ma, J Yu, X Wang… - Frontiers in …, 2020 - frontiersin.org
The formation of the B cell receptor (BCR) heavy chain variable region is derived from the
germline V (D) J gene rearrangement according to the “12/23” rule and the “beyond 12/23” …
germline V (D) J gene rearrangement according to the “12/23” rule and the “beyond 12/23” …
An updated definition of V (D) J recombination signal sequences revealed by high-throughput recombination assays
W Hoolehan, JC Harris, JN Byrum… - Nucleic Acids …, 2022 - academic.oup.com
In the adaptive immune system, V (D) J recombination initiates the production of a diverse
antigen receptor repertoire in developing B and T cells. Recombination activating proteins …
antigen receptor repertoire in developing B and T cells. Recombination activating proteins …
Modelling the T-cell repertoires of circulating T-cells and its application in cardiovascular diseases
K Le Gouge - 2023 - theses.hal.science
Cardiovascular diseases (CVD) are the leading cause of mortality in Europe, surpassing
various cancers, and are a major current public health concern. The immune system is …
various cancers, and are a major current public health concern. The immune system is …
Be Prospective, Not Retrospective: A Philosophy for Advancing Reproducibility in Modern Biological Research
G Chure - arXiv preprint arXiv:2210.02593, 2022 - arxiv.org
The ubiquity of computation in modern scientific research inflicts new challenges for
reproducibility. While most journals now require code and data be made available, the …
reproducibility. While most journals now require code and data be made available, the …
High Throughput Characterization of V (D) J Recombination Signal Sequences Redefines the Consensus Sequence
W Hoolehan, JC Harris, JN Byrum, KK Rodgers - bioRxiv, 2021 - biorxiv.org
In the adaptive immune system, V (D) J recombination initiates the production of a diverse
antigen receptor repertoire in developing B and T cells. Recombination activating proteins …
antigen receptor repertoire in developing B and T cells. Recombination activating proteins …