The mechanism and role of ADAMTS protein family in osteoarthritis
T Li, J Peng, Q Li, Y Shu, P Zhu, L Hao - Biomolecules, 2022 - mdpi.com
Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized
by the inflammation of the bone leading to degeneration and loss of cartilage function …
by the inflammation of the bone leading to degeneration and loss of cartilage function …
Protective effects of PACAP in peripheral organs
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide widely
distributed in the nervous system, where it exerts strong neuroprotective effects. PACAP is …
distributed in the nervous system, where it exerts strong neuroprotective effects. PACAP is …
The role of substance P in the regulation of bone and cartilage metabolic activity
FXZ Li, F Xu, X Lin, F Wu, JY Zhong, Y Wang… - Frontiers in …, 2020 - frontiersin.org
Substance P (SP) is a neuropeptide that is released from sensory nerve endings and is
widely present in nerve fibers. It acts on bones and related tissues by binding to receptors …
widely present in nerve fibers. It acts on bones and related tissues by binding to receptors …
Osteoarthritis and cartilage regeneration: Focus on pathophysiology and molecular mechanisms
S Grässel, A Aszodi - International Journal of Molecular Sciences, 2019 - mdpi.com
Osteoarthritis (OA) is a leading cause of disability and source of societal cost in older adults.
It is a whole-joint disease in which all components of the joint are affected involving …
It is a whole-joint disease in which all components of the joint are affected involving …
[HTML][HTML] Moxibustion ameliorates osteoarthritis by regulating gut microbiota via impacting cAMP-related signaling pathway
L Fu, H Duan, Y Cai, X Chen, B Zou, L Yuan… - Biomedicine & …, 2024 - Elsevier
Background Osteoarthritis (OA) is a prevalent progressive disorder. Moxibustion has found
widespread use in clinical practice for OA, while its underlying mechanism remains elusive …
widespread use in clinical practice for OA, while its underlying mechanism remains elusive …
[HTML][HTML] Macrophage polarization and alveolar bone healing outcome: despite a significant M2 polarizing effect, VIP and PACAP treatments present a minor impact in …
MCS Azevedo, AC Fonseca, PM Colavite… - Frontiers in …, 2021 - frontiersin.org
Host inflammatory immune response comprises an essential element of the bone healing
process, where M2 polarization allegedly contributes to a favorable healing outcome. In this …
process, where M2 polarization allegedly contributes to a favorable healing outcome. In this …
NSAIDs inhibit bone healing through the downregulation of TGF-β3 expression during endochondral ossification
Abstract Introduction & aims Non Steroidal Anti-Inflammatory drugs (NSAIDs) are potent
inhibitors of post-traumatic pain. Several studies have highlighted that NSAIDs could exert a …
inhibitors of post-traumatic pain. Several studies have highlighted that NSAIDs could exert a …
Substance P, a promising therapeutic target in musculoskeletal disorders
KR Ko, H Lee, SH Han, W Ahn, DK Kim, IS Kim… - International Journal of …, 2022 - mdpi.com
A large number of studies have focused on the role of substance P (SP) and the neurokinin-
1 receptor (NK1R) in the pathogenesis of a variety of medical conditions. This review …
1 receptor (NK1R) in the pathogenesis of a variety of medical conditions. This review …
Extract of Deschampsia antarctica (EDA) Prevents Dermal Cell Damage Induced by UV Radiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin
A Zamarrón, E Morel, SR Lucena, M Mataix… - International journal of …, 2019 - mdpi.com
Exposure to natural and artificial light and environmental pollutants are the main factors that
challenge skin homeostasis, promoting aging or even different forms of skin cancer through …
challenge skin homeostasis, promoting aging or even different forms of skin cancer through …
Magnetically controlled 3D cartilage regeneration
X Chen, R Zhang, Q Zhang, Z Xu, F Xu, D Li, Y Li - Cartilage, 2024 - journals.sagepub.com
Objective The cartilage regeneration field has not yet overcome the issue of effective
“shaping”: growing regenerated cartilage in the desired shape, and maintaining that shape …
“shaping”: growing regenerated cartilage in the desired shape, and maintaining that shape …