Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized
by the inflammation of the bone leading to degeneration and loss of cartilage function …

Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide widely
distributed in the nervous system, where it exerts strong neuroprotective effects. PACAP is …

Substance P (SP) is a neuropeptide that is released from sensory nerve endings and is
widely present in nerve fibers. It acts on bones and related tissues by binding to receptors …

Osteoarthritis (OA) is a leading cause of disability and source of societal cost in older adults.
It is a whole-joint disease in which all components of the joint are affected involving …

Background Osteoarthritis (OA) is a prevalent progressive disorder. Moxibustion has found
widespread use in clinical practice for OA, while its underlying mechanism remains elusive …

Host inflammatory immune response comprises an essential element of the bone healing
process, where M2 polarization allegedly contributes to a favorable healing outcome. In this …

Abstract Introduction & aims Non Steroidal Anti-Inflammatory drugs (NSAIDs) are potent
inhibitors of post-traumatic pain. Several studies have highlighted that NSAIDs could exert a …

A large number of studies have focused on the role of substance P (SP) and the neurokinin-
1 receptor (NK1R) in the pathogenesis of a variety of medical conditions. This review …

Exposure to natural and artificial light and environmental pollutants are the main factors that
challenge skin homeostasis, promoting aging or even different forms of skin cancer through …

Objective The cartilage regeneration field has not yet overcome the issue of effective
“shaping”: growing regenerated cartilage in the desired shape, and maintaining that shape …