Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules
Helminths are extraordinarily successful parasites due to their ability to modulate the host
immune response. They have evolved a spectrum of immunomodulatory molecules that are …
immune response. They have evolved a spectrum of immunomodulatory molecules that are …
Innate lymphoid cells: diversity, plasticity, and unique functions in immunity
M Colonna - Immunity, 2018 - cell.com
Type 1, 2, and 3 innate lymphoid cells (ILCs) have emerged as tissue-resident innate
correlates of T helper 1 (Th1), Th2, and Th17 cells. Recent studies suggest that ILCs are …
correlates of T helper 1 (Th1), Th2, and Th17 cells. Recent studies suggest that ILCs are …
The group 2 innate lymphoid cell (ILC 2) regulatory network and its underlying mechanisms
Group 2 innate lymphoid cells (ILC 2s) play critical roles in the induction of type 2
inflammation, response to parasite infection, metabolic homeostasis, and tissue repair …
inflammation, response to parasite infection, metabolic homeostasis, and tissue repair …
Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing
The impact of the microenvironment on innate lymphoid cell (ILC)-mediated immunity in
humans remains largely unknown. Here we used full-length Smart-seq2 single-cell RNA …
humans remains largely unknown. Here we used full-length Smart-seq2 single-cell RNA …
Prostaglandin‐cytokine crosstalk in chronic inflammation
C Yao, S Narumiya - British journal of pharmacology, 2019 - Wiley Online Library
Chronic inflammation underlies various debilitating disorders including autoimmune,
neurodegenerative, vascular and metabolic diseases as well as cancer, where aberrant …
neurodegenerative, vascular and metabolic diseases as well as cancer, where aberrant …
Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity
CSN Klose, D Artis - Cell research, 2020 - nature.com
The multifaceted organization of the immune system involves not only patrolling
lymphocytes that constantly monitor antigen-presenting cells in secondary lymphoid organs …
lymphocytes that constantly monitor antigen-presenting cells in secondary lymphoid organs …
Group 2 innate lymphoid cells in airway diseases
A Kato - Chest, 2019 - Elsevier
Group 2 innate lymphoid cells (ILC2s) are increasingly recognized as a key controller of type
2 inflammation, and are well known to be highly elevated in human airway type 2 …
2 inflammation, and are well known to be highly elevated in human airway type 2 …
Urinary Leukotriene E4 and Prostaglandin D2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical …
Rationale: New approaches are needed to guide personalized treatment of asthma.
Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping …
Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping …
Roles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s
KR Bartemes, H Kita - Journal of Allergy and Clinical Immunology, 2021 - Elsevier
In the 12 years since the discovery of innate lymphoid cells (ILCs), our knowledge of their
immunobiology has expanded rapidly. Group 2 ILCs (ILC2s) respond rapidly to allergen …
immunobiology has expanded rapidly. Group 2 ILCs (ILC2s) respond rapidly to allergen …
Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans
F Puttur, L Denney, LG Gregory, J Vuononvirta… - Science …, 2019 - science.org
Group 2 innate lymphoid cells (ILC2s) are enriched in mucosal tissues (eg, lung) and
respond to epithelial cell–derived cytokines initiating type 2 inflammation. During …
respond to epithelial cell–derived cytokines initiating type 2 inflammation. During …