Microdialysis (MD) was introduced as an intracerebral sampling method for clinical
neurosurgery by Hillered et al. and Meyerson et al. in 1990. Since then MD has been …

l-Glutamate (Glu) homeostasis in brain extracellular fluids and its maintenance at low
micromolar concentrations in the face of the extremely high Glu concentrations present in …

Microdialysis enables the chemistry of the extracellular interstitial space to be monitored.
Use of this technique in patients with acute brain injury has increased our understanding of …

Interictal brain energy metabolism and glutamate–glutamine cycling are impaired in
epilepsy and may contribute to seizure generation. We used the zero‐flow microdialysis …

Erythrocyte glutathione depletion has been linked to hemolysis and oxidative stress.
Glutamine plays an additional antioxidant role through preservation of intracellular …

Objective Aberrant glutamate and γ‐aminobutyric acid (GABA) neurotransmission contribute
to seizure generation and the epileptic state. However, whether levels of these …

Brain insults are characterized by a multitude of complex processes, of which glutamate
release plays a major role. Deleterious excess of glutamate in the brain's extracellular fluids …

Objective To perform a systematic review on commonly measured cerebral microdialysis
(CMD) analytes and their association to:(A) patient functional outcome,(B) neurophysiologic …

Excess glutamate in brain fluids characterizes acute brain insults such as traumatic brain
injury and stroke. Its removal could prevent the glutamate excitotoxicity that causes long …

Background Decreasing blood glutamate concentrations after traumatic brain injury
accelerates brain-to-blood glutamate efflux, leading to improved neurologic outcomes. The …