In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has
received much attention. This because they have shown in many cases enhanced …

Isocyanides were formally discovered by Gautier1 and Hofmann2 in 1867 but the history of
isocyanide chemistry in fact predates this discovery. Lieke carried out the first isocyanide …

The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole
synthesis. Fifteen examples and their mild cleavage products are described in satisfactory to …

Lactams are very important heterocycles as a result of their presence in a wide range of
bioactive molecules, natural products and drugs, and also due their utility as versatile …

1, 5-Disubstituted tetrazoles are an important drug-like scaffold known for their ability to
mimic the cis-amide bond conformation. The scaffold is readily accessible via substitution of …

Efficient access to a large chemical space based on new scaffolds with defined 3D
conformations and highly variable in the side chains is needed to find novel functional …

The synthesis of a variety of 2, 3-disubstituted quinolines has been achieved successfully
via a one-pot three-component reaction of arylamines, arylaldehydes and aliphatic …

Novel, one-pot, two-step, sequential protocols for the synthesis of 1, 4-phenylene
bisheterocyclic compounds have been developed. Successive sequencing of the Groebke …

Ugi-azide four-component reaction (UA-4CR) as development on Ugi four-component
reaction (U-4CR) is the condensation reaction involving an aldehyde, an amine, an …

A new series of tetrazole series of tetrazole tetrahydrobenzo [b] thiophene (10a-l) were
synthesized and evaluated as antileishmanial activity and cytotoxicity of in vitro. The results …