[HTML][HTML] Cysteine proteases: Battling pathogenic parasitic protozoans with omnipresent enzymes

A Rawat, M Roy, A Jyoti, S Kaushik, K Verma… - Microbiological …, 2021 - Elsevier
Millions of people worldwide lie at the risk of parasitic protozoic infections that kill over a
million people each year. The rising inefficacy of conventional therapeutics to combat these …

Covalent small-molecule inhibitors of SARS-CoV-2 Mpro: Insights into their design, classification, biological activity, and binding interactions

AM Shawky, FA Almalki, HA Alzahrani… - European Journal of …, 2024 - Elsevier
Since 2020, many compounds have been investigated for their potential use in the treatment
of SARS-CoV-2 infection. Among these agents, a huge number of natural products and FDA …

The man, the plant, and the insect: shooting host specificity determinants in Serratia marcescens pangenome

AE Shikov, AV Merkushova, IA Savina… - Frontiers in …, 2023 - frontiersin.org
Introduction Serratia marcescens is most commonly known as an opportunistic pathogen
causing nosocomial infections. It, however, was shown to infect a wide range of hosts apart …

New insights into the role of cysteine cathepsins in neuroinflammation

A Pišlar, L Bolčina, J Kos - Biomolecules, 2021 - mdpi.com
Neuroinflammation, which is mediated by microglia and astrocytes, is associated with the
progression of neurodegenerative diseases. Increasing evidence shows that activated …

功能蛋白酶催化及应用进展.

周北雅, 郭艳东, 薛雅鞠, 袁江月… - Chinese Journal of …, 2023 - search.ebscohost.com
蛋白酶广泛存在于动物, 植物及微生物体内, 在生物体内的代谢和合成过程中发挥着重要作用,
也是一种重要的工业酶制剂, 其中, 微生物蛋白酶几乎占据着全球商业蛋白酶的三分之二 …

[HTML][HTML] Endogenous cysteine protease inhibitors in upmost pathogenic parasitic protozoa

M Roy, A Rawat, S Kaushik, A Jyoti… - Microbiological …, 2022 - Elsevier
The regulation of the activity of proteases by endogenous inhibitors is a common trend in
almost all forms of life. Here, we review the endogenous inhibitors of cysteine proteases of …

Collateral beauty in the damages: an overview of cosmetics and therapeutic applications of microbial proteases

SS Mousavi Ghahfarrokhi, FS Mahdigholi… - Archives of …, 2023 - Springer
Microbial proteases are enzymes secreted by a variety of microorganisms, including
bacteria and fungi, and have attracted significant attention due to their versatile applications …

Silencing Ditylenchus destructor cathepsin L-like cysteine protease has negative pleiotropic effect on nematode ontogenesis

G Huang, Z Cong, Z Liu, F Chen, A Bravo… - Scientific Reports, 2024 - nature.com
Ditylenchus destructor is a migratory plant-parasitic nematode that severely harms many
agriculturally important crops. The control of this pest is difficult, thus efficient strategies for its …

Omp19 Enables Brucella abortus to Evade the Antimicrobial Activity From Host's Proteolytic Defense System

KA Pasquevich, MV Carabajal, FF Guaimas… - Frontiers in …, 2019 - frontiersin.org
Pathogenic microorganisms confront several proteolytic events in the molecular interplay
with their host, highlighting that proteolysis and its regulation play an important role during …

[HTML][HTML] CaZingipain2 Acts Positively in Pepper (Capsicum annuum L.) Immunity against R. solanacearum

R Wu, Z Wu, Y Qing, C Duan, Y Guo, X Zhang… - Plants, 2024 - mdpi.com
Bacterial wilt caused by Ralstonia solanacearum is one of the most important diseases in
solanaceous plants, including peppers. It generally tends to be more serious under warm …