Background The investigation of treatment mechanisms in randomized controlled trials has
considerable clinical and theoretical relevance. Despite the empirical support for the effect of …

BACKGROUND: Mindfulness-based cognitive therapy (MBCT) is a group-based clinical
intervention program designed to reduce relapse or recurrence of major depressive disorder …

The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published
treatment guidelines for bipolar disorder in 2005, along with international commentaries and …

Background: Major Depressive Disorder (MDD) is a highly prevalent, recurrent, and
potentially chronic disorder. Identifying risk factors and underlying mechanisms to inform …

Due to the clinical and etiological heterogeneity of major depressive disorder, it has been
difficult to elucidate its pathophysiology. Current neurobiological theories with the most valid …

Major depressive disorder (MDD) is highly disabling and typically runs a recurrent course.
Knowledge about prevention of relapse and recurrence is crucial to the long-term welfare of …

We propose a framework to understand increases in vulnerability for depression after
recurrent episodes that links attention processes and schema activation to negative mood …

Hardeveld F, Spijker J, De Graaf R, Nolen WA, Beekman ATF. Prevalence and predictors of
recurrence of major depressive disorder in the adult population. Objective: Knowledge of the …

Objective We aimed to review clinical features and biological underpinnings related to
neuroprogression in bipolar disorder (BD). Also, we discussed areas of controversy and …

Objective It is a widely held belief that affective disorders are progressive of nature; however,
some recent reviews have questioned this belief. The objective of the present systematic …