Neurodegenerative diseases affect not only the life quality of aging populations, but also
their life spans. All forms of neurodegenerative diseases have a massive impact on the …

Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to
modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen …

Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal
differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis …

Huntington's disease is an autosomal dominant, progressive neurodegenerative disorder,
for which there is no disease-modifying treatment. By use of predictive genetic testing, it is …

Recent advancements and growing attention about free radicals (ROS) and redox signaling
enable the scientific fraternity to consider their involvement in the pathophysiology of …

Huntington's disease (HD) is the most common polyglutamine neurodegenerative disorder
in humans, and is caused by a mutation of an unstable expansion of CAG repeats within the …

Backgorund: Oxidative stress is one of the main contributing factors involved in cerebral
biochemical impairment. The higher susceptibility of the central nervous system to reactive …

This study examined global oxidative stress (GOS) and antioxidant system and their
correlation with disease stage in 19 patients with HD. The results revealed an increase in …

The neuropathological hallmark of the autosomal dominantly inherited, neurodegenerative
disorder Huntington's disease is progressive striatal loss starting several years prior to …