In order to establish productive infection in women, HIV must transverse the vaginal
epithelium and gain access to local target cells. Genital inflammation contributes to the …

Short peptides are poorly immunogenic when delivered sublingually–under the tongue.
Nanomaterial delivery of peptides could be utilized to improve immunogenicity towards …

The novel coronavirus disease (COVID-19) and its infamous" Variants" of the etiological
agent termed Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has …

Antibodies mediate a broad array of non-neutralizing Fc-mediated functions against HIV-1
including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular …

Production of monomeric IgA in mammalian cells and plant expression systems such as
Nicotiana benthamiana is well-established and can be achieved by co-expression of the …

Preclinical studies have shown that the induction of secretory IgA (sIgA) in mucosa and
neutralizing antibodies (NAbs) in sera is essential for designing vaccines that can effectively …

The modest protective effects of the RV144 HIV-1 vaccine trial have prompted the further
exploration of improved poxvirus vector systems that can yield better immune responses and …

HIV-1 remains a major public health issue worldwide in spite of efficacious antiviral
therapies, but with no cure or preventive vaccine. The latter has been very challenging, as …

Methods: Plasma samples from people with chronic liver disease were analyzed using the
BioPoint POC dIgA ratio antigen immunoassay lateral flow test. Cirrhosis was defined by …

Human Immunodeficiency Virus type-1 (HIV-1) establishes a latent viral reservoir soon after
infection, which poses a major challenge for drug treatment and curative strategies. Many …