Age and sex are critical factors in ischemic stroke pathology

M Roy-O'Reilly, LD McCullough - Endocrinology, 2018 - academic.oup.com
Ischemic stroke is a devastating brain injury resulting in high mortality and substantial loss of
function. Understanding the pathophysiology of ischemic stroke risk, mortality, and functional …

Sex differences in stroke: challenges and opportunities

CD Bushnell, S Chaturvedi, KR Gage… - Journal of Cerebral …, 2018 - journals.sagepub.com
Biologic sex influences many variables that are important to brain health in general, and to
stroke or cerebral ischemia in particular, such as general health status, cerebrovascular …

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

QZ Tuo, P Lei, KA Jackman, XL Li, H Xiong… - Molecular …, 2017 - nature.com
Functional failure of tau contributes to age-dependent, iron-mediated neurotoxicity, and as
iron accumulates in ischemic stroke tissue, we hypothesized that tau failure may exaggerate …

Sex differences in cognitive impairment and Alzheimer's disease

R Li, M Singh - Frontiers in neuroendocrinology, 2014 - Elsevier
Studies have shown differences in specific cognitive ability domains and risk of Alzheimer's
disease between the men and women at later age. However it is important to know that sex …

Sulfide catabolism ameliorates hypoxic brain injury

E Marutani, M Morita, S Hirai, S Kai… - Nature …, 2021 - nature.com
The mammalian brain is highly vulnerable to oxygen deprivation, yet the mechanism
underlying the brain's sensitivity to hypoxia is incompletely understood. Hypoxia induces …

MicroRNA-based therapeutics in central nervous system injuries

P Sun, DZ Liu, GC Jickling… - Journal of Cerebral …, 2018 - journals.sagepub.com
Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …

Sex differences in the brain: Implications for behavioral and biomedical research

E Choleris, LAM Galea, F Sohrabji, KM Frick - … & Biobehavioral Reviews, 2018 - Elsevier
Biological differences between males and females are found at multiple levels. However,
females have too often been under-represented in behavioral neuroscience research, which …

Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes

MJ Reeves, CD Bushnell, G Howard… - The Lancet …, 2008 - thelancet.com
Stroke has a greater effect on women than men because women have more events and are
less likely to recover. Age-specific stroke rates are higher in men, but, because of their …

Mechanisms of brain injury after intracerebral haemorrhage

G Xi, RF Keep, JT Hoff - The Lancet Neurology, 2006 - thelancet.com
The past decade has resulted in a rapid increase in knowledge of mechanisms underlying
brain injury induced by intracerebral haemorrhage (ICH). Animal studies have suggested …

Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease

AC Boese, SC Kim, KJ Yin, JP Lee… - American Journal of …, 2017 - journals.physiology.org
Sex differences between women and men are often overlooked and underappreciated when
studying the cardiovascular system. It has been long assumed that men and women are …