Caspase‐3: structure, function, and biotechnological aspects
Abstract Caspase‐3, a cysteine‐aspartic acid protease, has recently attracted much
attention because of its incredible roles in tissue differentiation, regeneration, and neural …
attention because of its incredible roles in tissue differentiation, regeneration, and neural …
Calpain research for drug discovery: challenges and potential
Y Ono, TC Saido, H Sorimachi - Nature Reviews Drug Discovery, 2016 - nature.com
Calpains are a family of proteases that were scientifically recognized earlier than
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …
proteasomes and caspases, but remain enigmatic. However, they are known to participate in …
[HTML][HTML] The role of calpains in skeletal muscle remodeling with exercise and inactivity-induced atrophy
Calpains are cysteine proteases expressed in skeletal muscle fibers and other cells.
Although calpain was first reported to act as a kinase activating factor in skeletal muscle, the …
Although calpain was first reported to act as a kinase activating factor in skeletal muscle, the …
[HTML][HTML] CD44 mediates shear stress mechanotransduction in an in vitro blood-brain barrier model through small GTPases RhoA and Rac1
Fluid shear stress is an important mediator of vascular permeability, yet the molecular
mechanisms underlying the effect of shear on the blood-brain barrier (BBB) have yet to be …
mechanisms underlying the effect of shear on the blood-brain barrier (BBB) have yet to be …
Subcortical cytoskeleton periodicity throughout the nervous system
Superresolution fluorescence microscopy recently revealed a~ 190 nm periodic
cytoskeleton lattice consisting of actin, spectrin and other proteins underneath the …
cytoskeleton lattice consisting of actin, spectrin and other proteins underneath the …
Sex-based differences of antioxidant enzyme nanoparticle effects following traumatic brain injury
Following traumatic brain injury (TBI), reactive oxygen species (ROS) are released in
excess, causing oxidative stress, carbonyl stress, and cell death, which induce the additional …
excess, causing oxidative stress, carbonyl stress, and cell death, which induce the additional …
Distinct translatome changes in specific neural populations precede electroencephalographic changes in prion-infected mice
Selective vulnerability is an enigmatic feature of neurodegenerative diseases (NDs),
whereby a widely expressed protein causes lesions in specific cell types and brain regions …
whereby a widely expressed protein causes lesions in specific cell types and brain regions …
Time courses of post-injury mitochondrial oxidative damage and respiratory dysfunction and neuronal cytoskeletal degradation in a rat model of focal traumatic brain …
Traumatic brain injury (TBI) results in rapid reactive oxygen species (ROS) production and
oxidative damage to essential brain cellular components leading to neuronal dysfunction …
oxidative damage to essential brain cellular components leading to neuronal dysfunction …
Inhibition of NMDA receptors prevents the loss of BDNF function induced by amyloid β
SR Tanqueiro, RM Ramalho, TM Rodrigues… - Frontiers in …, 2018 - frontiersin.org
Brain-derived neurotrophic factor (BDNF) plays important functions in cell survival and
differentiation, neuronal outgrowth and plasticity. In Alzheimer's disease (AD), BDNF …
differentiation, neuronal outgrowth and plasticity. In Alzheimer's disease (AD), BDNF …
Calpains for dummies: What you need to know about the calpain family
S Spinozzi, S Albini, H Best, I Richard - Biochimica et Biophysica Acta (BBA …, 2021 - Elsevier
This review was written in memory of our late friend, Dr. Hiroyuki Sorimachi, who, following
the steps of his mentor Koichi Suzuki, a pioneer in calpain research, has made tremendous …
the steps of his mentor Koichi Suzuki, a pioneer in calpain research, has made tremendous …