The protein kinases regulate cellular functions such as transcription, translation,
proliferation, growth and survival by the process of phosphorylation. Over activation of …

Human cells in culture have a limited proliferative capacity. After a period of vigorous
proliferation, the rate of cell division declines and a number of changes occur in the cells …

Cellular senescence is a stress response mechanism that limits tumorigenesis and tissue
damage. Induction of cellular senescence commonly coincides with an immunogenic …

Oncogene-induced senescence is an important mechanism by which normal cells are
restrained from malignant transformation. Here we report that the suppression of the c-Myc …

Mammalian models of longevity are related primarily to caloric restriction and alterations in
metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 …

Keloids are benign skin tumors characterized by collagen accumulation and
hyperproliferation of fibroblasts. To find an effective therapy for keloids, we explored the …

Pharmacologic inhibition of the DNA signal transducers Chk1 and p38 blocks G2 arrest and
sensitizes glioblastoma cells to chemotherapeutic methylating agent–induced cytotoxicity …

The extracellular signal-regulated kinase 1 and 2 (ERK1/2) mitogen-activated protein (MAP)
kinase signaling pathway plays an important role in the proliferative response of mammalian …

Aging is a multifactorial universal process characterized by a gradual decrease in
physiological and biochemical functions. Given that life expectancy is on the rise, a better …

Our study aimed at validating the effect of WISP1 on osteoarthritis (OA) and the pathway
involved in the WISP1-induced protection against OA. The expression of WISP1 was …