Human pluripotent stem (hPS) cells can, in theory, be differentiated into any cell type,
making them a powerful in vitro model for human biology. Recent technological advances …

During brain development, the sequence of developmental steps and the underlying
transcriptional regulatory logic are largely conserved across species. However, the temporal …

Aging is the biggest risk factor for the development of Alzheimer's disease (AD). Here, we
performed a whole-genome CRISPR screen to identify regulators of neuronal age and show …

The evolution of the modern human brain was accompanied by distinct molecular and
cellular specializations, which underpin our diverse cognitive abilities but also increase our …

Development consists of a highly ordered suite of steps and transitions, like choreography.
Although these sequences are often evolutionarily conserved, they can display species …

Brain organoids hold great potential for modeling human brain development and
pathogenesis. They recapitulate certain aspects of the transcriptional trajectory, cellular …

Embryonic neurodevelopment, particularly neural progenitor differentiation into post-mitotic
neurons, has been extensively studied. While the number and composition of post-mitotic …

The complicated process of neuronal development is initiated early in life, with the genetic
mechanisms governing this process yet to be fully elucidated. Single-cell RNA sequencing …

Sandfly-borne Toscana virus (TOSV) is an enveloped tri-segmented negative single-strand
RNA Phlebovirus. It is an emerging virus predominantly endemic in southwestern Europe …

This year marks the tenth anniversary of the world's first transplantation of tissue generated
from induced pluripotent stem cells (iPSCs). There is now a growing number of clinical trials …