Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases
Human pluripotent stem (hPS) cells can, in theory, be differentiated into any cell type,
making them a powerful in vitro model for human biology. Recent technological advances …
making them a powerful in vitro model for human biology. Recent technological advances …
[HTML][HTML] Epigenetic control and manipulation of neuronal maturation timing
During brain development, the sequence of developmental steps and the underlying
transcriptional regulatory logic are largely conserved across species. However, the temporal …
transcriptional regulatory logic are largely conserved across species. However, the temporal …
Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration
Aging is the biggest risk factor for the development of Alzheimer's disease (AD). Here, we
performed a whole-genome CRISPR screen to identify regulators of neuronal age and show …
performed a whole-genome CRISPR screen to identify regulators of neuronal age and show …
A molecular and cellular perspective on human brain evolution and tempo
The evolution of the modern human brain was accompanied by distinct molecular and
cellular specializations, which underpin our diverse cognitive abilities but also increase our …
cellular specializations, which underpin our diverse cognitive abilities but also increase our …
Metabolic mechanisms of species-specific developmental tempo
R Iwata, P Vanderhaeghen - Developmental Cell, 2024 - cell.com
Development consists of a highly ordered suite of steps and transitions, like choreography.
Although these sequences are often evolutionarily conserved, they can display species …
Although these sequences are often evolutionarily conserved, they can display species …
Multiscale engineering of brain organoids for disease modeling
C Xu, A Alameri, W Leong, E Johnson, Z Chen… - Advanced Drug Delivery …, 2024 - Elsevier
Brain organoids hold great potential for modeling human brain development and
pathogenesis. They recapitulate certain aspects of the transcriptional trajectory, cellular …
pathogenesis. They recapitulate certain aspects of the transcriptional trajectory, cellular …
Gene-environmental regulation of the postnatal post-mitotic neuronal maturation
GS Prince, M Reynolds, V Martina, HS Sun - Trends in Genetics, 2024 - cell.com
Embryonic neurodevelopment, particularly neural progenitor differentiation into post-mitotic
neurons, has been extensively studied. While the number and composition of post-mitotic …
neurons, has been extensively studied. While the number and composition of post-mitotic …
Single-cell RNA-seq data analysis reveals functionally relevant biomarkers of early brain development and their regulatory footprints in human embryonic stem cells …
M Alamin, M Humaira Sultana… - Briefings in …, 2024 - academic.oup.com
The complicated process of neuronal development is initiated early in life, with the genetic
mechanisms governing this process yet to be fully elucidated. Single-cell RNA sequencing …
mechanisms governing this process yet to be fully elucidated. Single-cell RNA sequencing …
Numb-associated kinases regulate sandfly-borne Toscana virus entry.
Y Moalem, R Katz, AG Subramaniam… - Emerging Microbes & …, 2024 - Taylor & Francis
Sandfly-borne Toscana virus (TOSV) is an enveloped tri-segmented negative single-strand
RNA Phlebovirus. It is an emerging virus predominantly endemic in southwestern Europe …
RNA Phlebovirus. It is an emerging virus predominantly endemic in southwestern Europe …
iPS cell therapy 2.0: Preparing for next‐generation regenerative medicine
KK Hui, S Yamanaka - BioEssays, 2024 - Wiley Online Library
This year marks the tenth anniversary of the world's first transplantation of tissue generated
from induced pluripotent stem cells (iPSCs). There is now a growing number of clinical trials …
from induced pluripotent stem cells (iPSCs). There is now a growing number of clinical trials …