Anxiety disorders are a significant problem in the community, and recent neuroimaging
research has focused on determining the brain circuits that underlie them. Research on the …

OBJECTIVE: This article aims to review basic and clinical studies outlining the roles of
prefrontal cortical (PFC) networks in the behavior and cognitive functions that are …

Objective: Structural brain imaging studies in obsessive-compulsive disorder (OCD) have
produced inconsistent findings. This may be partially due to limited statistical power from …

Compulsivity is associated with alterations in the structure and the function of parallel and
interacting brain circuits involved in emotional processing (involving both the reward and the …

BackgroundSpecific cortico-striato-thalamic circuits are hypothesised to mediate the
symptoms of obsessive–compulsive disorder (OCD), but structural neuroimaging studies …

Obsessive-compulsive disorder (OCD) is a common, heritable and disabling
neuropsychiatric disorder. Theoretical models suggest that OCD is underpinned by …

Obsessive–compulsive disorder (OCD) was previously considered refractory to most types
of therapeutic intervention. There is now, however, ample evidence that selective serotonin …

Neuroimaging research has helped to advance neurobiological models of anxiety disorders.
The amygdala is known to play an important role in normal fear conditioning and is …

A thorough investigation of the neural effects of psychotherapy is needed in order to provide
a neurobiological foundation for widely used treatment protocols. This paper reviews …

Endophenotypes (intermediate phenotypes) are objective, heritable, quantitative traits
hypothesized to represent genetic risk for polygenic disorders at more biologically tractable …