Molecular inflammation: underpinnings of aging and age-related diseases
Recent scientific studies have advanced the notion of chronic inflammation as a major risk
factor underlying aging and age-related diseases. In this review, low-grade, unresolved …
factor underlying aging and age-related diseases. In this review, low-grade, unresolved …
Mechanisms of vascular aging: new perspectives
This review focuses on molecular, cellular, and functional changes that occur in the
vasculature during aging; explores the links between mitochondrial oxidative stress …
vasculature during aging; explores the links between mitochondrial oxidative stress …
The impact of cerebrovascular aging on vascular cognitive impairment and dementia
As human life expectancy rises, the aged population will increase. Aging is accompanied by
changes in tissue structure, often resulting in functional decline. For example, aging within …
changes in tissue structure, often resulting in functional decline. For example, aging within …
The molecular inflammatory process in aging
HY Chung, B Sung, KJ Jung, Y Zou… - Antioxidants & redox …, 2006 - liebertpub.com
Emerging pathological evidence indicates that major chronic aging-related diseases such
as atherosclerosis, arthritis, dementia, osteoporosis, and cardiovascular diseases, are …
as atherosclerosis, arthritis, dementia, osteoporosis, and cardiovascular diseases, are …
Killing me unsoftly: causes and mechanisms of arterial stiffness
AN Lyle, U Raaz - Arteriosclerosis, thrombosis, and vascular …, 2017 - Am Heart Assoc
The aorta is a blood vessel that provides a low-resistance path for blood flow directed from
the heart to peripheral organs and tissues. However, the aorta has another central …
the heart to peripheral organs and tissues. However, the aorta has another central …
Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study
LR Schouten, AH van Kaam, F Kohse, F Veltkamp… - Annals of intensive …, 2019 - Springer
Background Results from preclinical studies suggest that age-dependent differences in host
defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed …
defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed …
Nuclear factor-κB activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans
GL Pierce, LA Lesniewski, BR Lawson, SD Beske… - Circulation, 2009 - Am Heart Assoc
Background—We tested the hypothesis that nuclear factor-κB (NF-κB) activity contributes to
vascular endothelial dysfunction with aging and obesity in humans. Methods and Results …
vascular endothelial dysfunction with aging and obesity in humans. Methods and Results …
Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans
AJ Donato, AD Black, KL Jablonski, LB Gano… - Aging cell, 2008 - Wiley Online Library
The vascular endothelium may develop a proinflammatory profile with aging, but evidence is
limited in humans. Expression of inflammatory proteins was determined in vascular …
limited in humans. Expression of inflammatory proteins was determined in vascular …
Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging
Z Ungvari, C Parrado-Fernandez, A Csiszar… - Circulation …, 2008 - Am Heart Assoc
This review focuses on the emerging evidence that attenuation of the production of reactive
oxygen species and inhibition of inflammatory pathways play a central role in the antiaging …
oxygen species and inhibition of inflammatory pathways play a central role in the antiaging …
Diabetes and ageing‐induced vascular inflammation
ME Assar, J Angulo… - The Journal of …, 2016 - Wiley Online Library
Diabetes and the ageing process independently increase the risk for cardiovascular disease
(CVD). Since incidence of diabetes increases as people get older, the diabetic older adults …
(CVD). Since incidence of diabetes increases as people get older, the diabetic older adults …