Recent scientific studies have advanced the notion of chronic inflammation as a major risk
factor underlying aging and age-related diseases. In this review, low-grade, unresolved …

This review focuses on molecular, cellular, and functional changes that occur in the
vasculature during aging; explores the links between mitochondrial oxidative stress …

As human life expectancy rises, the aged population will increase. Aging is accompanied by
changes in tissue structure, often resulting in functional decline. For example, aging within …

Emerging pathological evidence indicates that major chronic aging-related diseases such
as atherosclerosis, arthritis, dementia, osteoporosis, and cardiovascular diseases, are …

The aorta is a blood vessel that provides a low-resistance path for blood flow directed from
the heart to peripheral organs and tissues. However, the aorta has another central …

Background Results from preclinical studies suggest that age-dependent differences in host
defense and the pulmonary renin–angiotensin system (RAS) are responsible for observed …

Background—We tested the hypothesis that nuclear factor-κB (NF-κB) activity contributes to
vascular endothelial dysfunction with aging and obesity in humans. Methods and Results …

The vascular endothelium may develop a proinflammatory profile with aging, but evidence is
limited in humans. Expression of inflammatory proteins was determined in vascular …

This review focuses on the emerging evidence that attenuation of the production of reactive
oxygen species and inhibition of inflammatory pathways play a central role in the antiaging …

Diabetes and the ageing process independently increase the risk for cardiovascular disease
(CVD). Since incidence of diabetes increases as people get older, the diabetic older adults …