Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by
removing acetyl groups from histones and other protein regulatory factors, with functional …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Insomnia is a serious worldwide health threat, affecting nearly one third of the general
population. Melatonin has been reported to improve sleep efficiency and it was found that …

Estrogen has pleiotropic effects on the cardiovascular system. The mechanisms by which
estrogen confers these pleiotropic effects are undergoing active investigation. Until a …

Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic
target in various diseases, including cancer, X-linked intellectual disability, and parasitic …

Numerous studies have highlighted the key roles of oxidative stress and inflammation in
aging‐related diseases such as obesity, type 2 diabetes, age‐related macular degeneration …

1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …

The dynamics of mitochondrial biogenesis and function is a complex interplay of cellular and
molecular processes that ultimately shape bioenergetics capacity. Mitochondrial mass, by …

Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …