Causal mapping of human brain function
Mapping human brain function is a long-standing goal of neuroscience that promises to
inform the development of new treatments for brain disorders. Early maps of human brain …
inform the development of new treatments for brain disorders. Early maps of human brain …
New and emerging approaches to treat psychiatric disorders
Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …
the lives of millions of people worldwide. Although their etiological and diagnostic …
Closed-loop neuromodulation in an individual with treatment-resistant depression
Deep brain stimulation is a promising treatment for neuropsychiatric conditions such as
major depression. It could be optimized by identifying neural biomarkers that trigger therapy …
major depression. It could be optimized by identifying neural biomarkers that trigger therapy …
Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease
Damage to specific brain circuits can cause specific neuropsychiatric symptoms.
Therapeutic stimulation to these same circuits may modulate these symptoms. To determine …
Therapeutic stimulation to these same circuits may modulate these symptoms. To determine …
The multifaceted role of the ventromedial prefrontal cortex in emotion, decision making, social cognition, and psychopathology
The ventromedial prefrontal cortex (vmPFC) has been implicated in a variety of social,
cognitive, and affective functions that are commonly disrupted in mental illness. In this …
cognitive, and affective functions that are commonly disrupted in mental illness. In this …
State-dependent responses to intracranial brain stimulation in a patient with depression
Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in
randomized trials raises questions regarding anatomical targeting. We implanted multi-site …
randomized trials raises questions regarding anatomical targeting. We implanted multi-site …
Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial
PE Holtzheimer, MM Husain, SH Lisanby… - The Lancet …, 2017 - thelancet.com
Background Deep brain stimulation (DBS) of the subcallosal cingulate white matter has
shown promise as an intervention for patients with chronic, unremitting depression. To test …
shown promise as an intervention for patients with chronic, unremitting depression. To test …
Connectivity predicts deep brain stimulation outcome in P arkinson disease
Objective The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may
depend on connectivity between the stimulation site and other brain regions, but which …
depend on connectivity between the stimulation site and other brain regions, but which …
Distinct symptom-specific treatment targets for circuit-based neuromodulation
SH Siddiqi, SF Taylor, D Cooke… - American Journal of …, 2020 - Am Psychiatric Assoc
Objective: Treatment of different depression symptoms may require different brain
stimulation targets with different underlying brain circuits. The authors sought to identify such …
stimulation targets with different underlying brain circuits. The authors sought to identify such …
How emotions are made: The secret life of the brain
LF Barrett - Pan Macmillan, 2017 - books.google.com
'How Emotions Are Made did what all great books do. It took a subject I thought I understood
and turned my understanding upside down'–Malcolm Gladwell, author of The Tipping Point …
and turned my understanding upside down'–Malcolm Gladwell, author of The Tipping Point …