The intestinal mucosa is a particularly dynamic environment in which the host constantly
interacts with trillions of commensal microorganisms, known as the microbiota, and …

A fundamental property of many plasma-membrane proteins is their association with the
underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

The highly conserved and ubiquitously expressed 14‐3‐3 proteins regulate differentiation,
cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in …

Mucosal repair is a complex event that immediately follows acute injury induced by ischemia
and noxious luminal contents such as bile. In the small intestine, villous contraction is the …

The colonic epithelium has both absorptive and secretory functions. The transport is
characterized by a net absorption of NaCl, short-chain fatty acids (SCFA), and water …

Sodium/proton antiporters or exchangers (NHE) are integral membrane proteins present in
most, if not all, living organisms. In mammals, these transporters chiefly catalyze the …

Diarrhoeal disease remains a major health burden worldwide. Secretory diarrhoeas are
caused by certain bacterial and viral infections, inflammatory processes, drugs and genetic …

The neurofibromatosis-2 (NF2) gene encodes merlin, an ezrin-radixin-moesin-(ERM)-
related protein that functions as a tumor suppressor. We found that merlin mediates contact …

Over the past 25 years, successive cloning of SLC34A1, SLC34A2 and SLC34A3, which
encode the sodium-dependent inorganic phosphate (Pi) cotransport proteins 2a–2c, has …