[HTML][HTML] Alternatives to biological skin in permeation studies: Current trends and possibilities

R Neupane, SHS Boddu, J Renukuntla, RJ Babu… - Pharmaceutics, 2020 - mdpi.com
The transdermal route of drugs has received increased attention in recent years due to
numerous advantages over the oral and injectable routes, such as avoidance of the hepatic …

Natural Ingredients of Transdermal Drug Delivery Systems as Permeation Enhancers of Active Substances through the Stratum Corneum

N Schafer, R Balwierz, P Biernat… - Molecular …, 2023 - ACS Publications
In recent years, significant progress has been made in transdermal drug delivery systems,
but there is still a search for enhancers that can improve the absorption of active substances …

Direct 3D cell-printing of human skin with functional transwell system

BS Kim, JS Lee, G Gao, DW Cho - Biofabrication, 2017 - iopscience.iop.org
Abstract Three-dimensional (3D) cell-printing has been emerging as a promising technology
with which to build up human skin models by enabling rapid and versatile design. Despite …

Porcine models of cutaneous wound healing

M Seaton, A Hocking, NS Gibran - ILAR journal, 2015 - academic.oup.com
Cutaneous wound healing in the pig is frequently used as a model for human cutaneous
wound healing. In this review, we examine the appropriateness of this model for studying …

[HTML][HTML] Comparison between Franz diffusion cell and a novel micro-physiological system for in vitro penetration assay using different skin models

I Pulsoni, M Lubda, M Aiello, A Fedi, M Marzagalli… - SLAS technology, 2022 - Elsevier
In vitro diffusive models are an important tool to screen the penetration ability of active
ingredients in various formulations. A reliable assessment of skin penetration enhancing …

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

S Gordon, M Daneshian, J Bouwstra, F Caloni… - …, 2015 - researchonline.ljmu.ac.uk
Models of the outer epithelia of the human body-namely the skin, the intestine and the lung-
have found valid applications in both research and industrial settings as attractive …

3D bioprinting of heterogeneous tissue-engineered skin containing human dermal fibroblasts and keratinocytes

M Li, L Sun, Z Liu, Z Shen, Y Cao, L Han, S Sang… - Biomaterials …, 2023 - pubs.rsc.org
Three-dimensional (3D) printed skin substitutes have great potential for wound healing.
However, current 3D printed skin models are limited in simulating heterogeneity and …

Ionic liquid–microemulsions assisting in the transdermal delivery of Dencichine: Preparation, in-vitro and in-vivo evaluations, and investigation of the permeation …

C Wang, J Zhu, D Zhang, Y Yang, L Zheng, Y Qu… - International journal of …, 2018 - Elsevier
A novel microemulsion was developed and characterized for topical delivery of Dencichine
(Den). Two imidazaolium ionic liquid, 1-hydroxyethyl-3-methylimidazolium chloride ([HOEIM] …

Ethosomes for enhanced skin delivery of griseofulvin

J Marto, C Vitor, A Guerreiro, C Severino… - Colloids and Surfaces B …, 2016 - Elsevier
Griseofulvin (GRF) is an important antifungal drug with low bioavailability and, for this
reason, a topical formulation with a targeted action and minimal systemic effects, appears to …

[HTML][HTML] Skin penetration and dermal tolerability of acrylic nanocapsules: Influence of the surface charge and a chitosan gel used as vehicle

RV Contri, LA Fiel, N Alnasif, AR Pohlmann… - International journal of …, 2016 - Elsevier
For an improved understanding of the relevant particle features for cutaneous use, we
studied the effect of the surface charge of acrylic nanocapsules (around 150 nm) and the …